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PMID: 6285344 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Novel features of animal mtDNA evolution as shown by sequences of two rat cytochrome oxidase subunit II genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 10 ·1982-05-00 ·Pages 3246-50

Brown GG, Simpson MV

Abstract

The sequence of the region of the mitochondrial genome that encodes cytochrome oxidase subunit II (COII) has been determined for each of two closely related rat species, Rattus norvegicus and R. rattus. Comparison of the two sequences shows that 94.4% of the nucleotide substitutions are silent. The occurrence of this high proportion of silent substitutions leads us to propose that the rapid evolution of mtDNA relative to nuclear DNA is due only to silent changes and that amino acid-altering substitutions accumulate in nuclear and mtDNA at comparable rates. Other novel features of the nucleotide substitution pattern in the rat COII gene are a high transition/transversion ratio (8.0:1) and a strong bias toward C in equilibrium T transitions in the light strand. Comparison of the R. norvegicus COII sequence with the bovine and human sequences show that there may be selective constraints on some silent positions within the gene and that its rate of evolution may be different in different mammalian lineages.

MeSH Terms
Animals Base Sequence Biological Evolution DNA, Mitochondrial/genetics Electron Transport Complex IV/genetics Genes Macromolecular Substances Muridae/genetics Mutation Rats
Chemicals
DNA, Mitochondrial Macromolecular Substances Electron Transport Complex IV
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brown G G
Simpson M V
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.10.3246
Published
1982-05-00
Pages
3246-50
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346392
Subset
IM
Grants
NIGMS NIH HHS · GM 06972 · United States
NIGMS NIH HHS · GM 22333-15 · United States
Databases
GENBANK
J01434, J01435
External Links
PubMed source DOI: 10.1073/pnas.79.10.3246 PMC Full Text View journal details
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