Estimation of DNA sequence divergence from comparison of restriction endonuclease digests.

Nucleic acids research ·Vol. 4 ·No. 5 ·1977-00-00 ·Pages 1257-65

Upholt WB

Abstract

An estimation of the DNA sequence divergence between defined DNA secquences of individuals or species may be made from comparison by gel electrophoresis of restriction endonuclease digests. This analysis is applicable to purified DNA sequence of moderate complexity (1-100 X 10(6) daltons) which have diverged by base substitution of 0.5 to 25% of nucleotides.

MeSH Terms

Base Sequence Biochemical Phenomena Biochemistry DNA DNA Restriction Enzymes Endonucleases Mathematics Methods Molecular Weight

Chemicals

DNA Endonucleases DNA Restriction Enzymes

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Upholt W B

References (9)

9 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/4.5.1257

Published

1977-00-00

Pages

1257-65

Language

English

Region

England

NLM ID

0411011

PMCID

PMC343753

Subset

External Links

PubMed source DOI: 10.1093/nar/4.5.1257 PMC Full Text View journal details

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Estimation of DNA sequence divergence from comparison of restriction endonuclease digests.

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