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PMID: 6284982 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DNA of herpesvirus pan, a third member of the Epstein-Barr virus-Herpesvirus papio group.

Journal of virology ·Vol. 41 ·No. 3 ·1982-03-00 ·Pages 931-9

Heller M, Gerber P, Kieff E

Abstract

The DNA of herpesvirus pan, a primate B-lymphotropic herpesvirus, shares about 40% well-conserved sequence relatedness with Epstein-Barr virus (EBV) and herpesvirus papio DNAs. Labeled cloned fragments from the EBV recombinant DNA library were cross hybridized to blots of EcoRI, XbaI, and BamHI restriction endonuclease fragments of herpesvirus pan DNA to identify and map homologous sequences in the herpesvirus pan genome. Regions of colinear homology were demonstrated between 6 x 10(6) daltons and 108 x 10(6) daltons in the DNAs. The structural organization of herpesvirus pan DNA was similar to the format of Epstein-Barr virus and herpesvirus papio DNAs. The DNA consists of two domains of largely unique sequence complexity, a segment US of 9 x 10(6) daltons and a segment UL of 88 x 10(6) daltons. US and UL are separated by a variable number of tandem repetitions of a sequence IR (2 x 10(6) daltons). There was homology between DNA which mapped at 26 to 28 x 10(6) daltons and 93 to 95 x 10(6) daltons in UL. The terminal reiteration component, TR, of herpesvirus pan DNA and sequences which mapped to the left of 6 x 10(6) daltons and to the right of 108 x 10(6) daltons had no detectable homology with the corresponding regions of Epstein-Barr virus DNA.

MeSH Terms
Base Sequence DNA Restriction Enzymes DNA, Viral/analysis Herpesviridae/classification,genetics Molecular Weight Nucleic Acid Hybridization Phylogeny Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Heller M
Gerber P
Kieff E
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38 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.41.3.931-939.1982
Published
1982-03-00
Pages
931-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256829
Subset
IM
Grants
NIAID NIH HHS · AI-07099 · United States
NCI NIH HHS · CA 17281 · United States
NCI NIH HHS · CA 19264 · United States
External Links
PubMed source DOI: 10.1128/JVI.41.3.931-939.1982 PMC Full Text View journal details
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