Monoclonal antibodies of four different specificities for neutralization of type 1 polioviruses.

Infection and immunity ·Vol. 36 ·No. 2 ·1982-05-00 ·Pages 841-3

Humphrey DD, Kew OM, Feorino PM

Abstract

Four independent hybridoma clones have been established that produce neutralizing antibodies specific to type 1 poliovirus. Each clone produced antibody which neutralized a distinct set of type 1 test strains: (i) all 15 strains tested; (ii) the inducer strain only; (iii) predominantly wild strains; or (iv) all vaccine-related and some wild strains.

MeSH Terms

Antibodies, Monoclonal/immunology Antibodies, Viral/immunology Antibody Specificity Hybridomas Neutralization Tests Poliovirus/immunology Poliovirus Vaccine, Inactivated/immunology

Chemicals

Antibodies, Monoclonal Antibodies, Viral Poliovirus Vaccine, Inactivated

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Humphrey D D

Kew O M

Feorino P M

References (8)

8 references, click to expand

Complement-fixing antigens produced by varicella-zoster virus in tissue culture.
Appl Microbiol. 1973 Sep;26(3):410-6 PMID: 4356464
A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.
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Production of monoclonal antibodies against nucleocapsid proteins of herpes simplex virus types 1 and 2.
J Virol. 1979 Nov;32(2):676-8 PMID: 91687
Changes in three of the four coat proteins of oral polio vaccine strain derived from type 1 poliovirus.
J Virol. 1980 Jan;33(1):256-63 PMID: 6245231
Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. II. The glycoprotein.
J Gen Virol. 1980 May;48(1):105-9 PMID: 6155432
Molecular variation of type 1 vaccine-related and wild polioviruses during replication in humans.
Virology. 1981 Jan 30;108(2):405-23 PMID: 6258294
Epidemiological implications of the isolations and intratypic serodifferentiation of poliovirus strains in the Netherlands.
Dev Biol Stand. 1981;47:293-301 PMID: 6262154
The use of a modified Wecker technique for the serodifferentiation of type 1 polioviruses related and unrelated to Sabin's vaccine strain. I. Standardization and evaluation of the test.
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.36.2.841-843.1982

Published

1982-05-00

Pages

841-3

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC351306

Subset

External Links

PubMed source DOI: 10.1128/iai.36.2.841-843.1982 PMC Full Text View journal details

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Monoclonal antibodies of four different specificities for neutralization of type 1 polioviruses.

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