Occurrence of transposable trimethoprim resistance in clinical isolates of Escherichia coli devoid of self-transmissible resistance plasmids.

Antimicrobial agents and chemotherapy ·Vol. 21 ·No. 2 ·1982-02-00 ·Pages 336-8

Towner KJ, Venning BM, Pinn PA

Abstract

Fifty trimethoprim-resistant clinical isolates of Escherichia coli, devoid of self transmissible trimethoprim resistance plasmids, were examined for the presence of trimethoprim resistance transposons. Trimethoprim resistance was mobilized from 12 strains by transposition onto plasmid RP4. The trimethoprim resistance transposons isolated comprised two groups: those with and without linked streptomycin resistance.

MeSH Terms

DNA Transposable Elements Drug Resistance, Microbial Escherichia coli/drug effects,genetics Plasmids Trimethoprim/pharmacology

Chemicals

DNA Transposable Elements Trimethoprim

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Towner K J

Venning B M

Pinn P A

References (8)

8 references, click to expand

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Regulatory mutants of dihydrofolate reductase in Escherichia coli K12.
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Tn402: a new transposable element determining trimethoprim resistance that inserts in bacteriophage lambda.
J Bacteriol. 1977 Mar;129(3):1632-5 PMID: 321437
Altered dihydrofolate reductase in fol regulatroy mutants of Escherichia coli K12.
Mol Gen Genet. 1977 Mar 7;151(2):215-9 PMID: 327267
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics.
J Mol Biol. 1977 Oct 15;116(1):125-59 PMID: 338917
Trimethoprim R plasmids isolated during long-term treatment of urinary tract infection with co-trimoxazole.
J Antimicrob Chemother. 1979 Jan;5(1):45-52 PMID: 762006
Plasmids and transposons and their stability and mutability in bacteria isolated during an outbreak of hospital infection.
Plasmid. 1979 Apr;2(2):182-96 PMID: 377321
A clinical isolate of Escherichia coli owing its trimethoprim resistance to a chromosomally-located trimethoprim transposon.
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.21.2.336

Published

1982-02-00

Pages

336-8

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC181883

Subset

External Links

PubMed source DOI: 10.1128/AAC.21.2.336 PMC Full Text View journal details

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Occurrence of transposable trimethoprim resistance in clinical isolates of Escherichia coli devoid of self-transmissible resistance plasmids.

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