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PMID: 6264159 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Virus-associated RNAs of naturally occurring strains and variants of group C adenoviruses.

Journal of virology ·Vol. 38 ·No. 3 ·1981-06-00 ·Pages 849-62

Mathews MB, Grodzicker T

Abstract

We compared the sequences of the virus-associated (VA) RNAs of group C adenoviruses, serotypes 1, 2, 5, and 6, and of three variants of adenovirus type 2 (Ad2) selected for loss of the BamHI restriction site in the VA RNAI gene. In the naturally occurring strains. VA RNAI exists in two forms which differ by two nucleotides: one form is found in Ad2 and Ad6, and the other is found in Ad1 and Ad5. There are three sites of variation in Va RNAII, the Ad1, Ad2, and Ad5 forms each differing from Ad6 VA RNAII at one of the positions. One of the selected variants has a four-base duplication within the BamHI cleavage site, whereas the two others have acquired a VA RNAI sequence indistinguishable from that of Ad5. The findings are interpreted in terms of the secondary structures of the VA RNAs and the interrelationships among the viruses.

MeSH Terms
Adenoviruses, Human/analysis,classification,genetics Base Sequence DNA Restriction Enzymes Deoxyribonuclease BamHI Genes, Viral Genetic Variation RNA, Viral Serotyping
Chemicals
RNA, Viral DNA Restriction Enzymes Deoxyribonuclease BamHI
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mathews M B
Grodzicker T
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45 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.38.3.849-862.1981
Published
1981-06-00
Pages
849-62
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC171222
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.38.3.849-862.1981 PMC Full Text View journal details
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