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PMID: 925035 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Studies of low molecular weight RNA from cells infected with adenovirus 2. II. Heterogeneity at the 5' end of VA-RNA I.

The Journal of biological chemistry ·Vol. 252 ·No. 24 ·1977-12-25 ·Pages 9043-6

Celma ML, Pan J, Weissman SM

Abstract

The 5'-terminal sequences of VA-RNA I produced in cells infected with adenovirus 2 were analyzed. The RNA contained a mixture of mono-, di-, and triphosphate ends. The largest part of the RNA has 5'-terminal mono-, di-, or triphosphoguanylic acid, but a portion of the RNA has a 5'-terminal mono-, di-, or triphosphoadenylic acid. An RNA with 5'-terminal adenylic acid was purified and gave the same oligonucleotide map as the major form of VA-RNA I, except for the 5'-terminal products. We therefore conclude that transcription of VA-RNA I can initiate at two different nearby sites.

MeSH Terms

Adenine Nucleotides/analysis Adenoviridae Base Sequence Guanine Nucleotides/analysis Oligoribonucleotides/analysis RNA, Viral Transcription, Genetic

Chemicals

Adenine Nucleotides Guanine Nucleotides Oligoribonucleotides RNA, Viral

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Celma M L

Pan J

Weissman S M

Article Info

Journal

The Journal of biological chemistry

Abbr.

J Biol Chem

ISSN

0021-9258

Published

1977-12-25

Pages

9043-6

Language

English

Region

United States

NLM ID

2985121R

Subset

Databases

GENBANK

J01917, J01918, J01919, J01920, J01921, J01922, J01923, J01924, J01925, J01926, J01927, J01928, J01929, J01930, J01931, J01932, J01933, J01934, J01935, J01936, J01937, J01938, J01939, J01940, J01941, J01942, J01943, J01944, J01945, J01946

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Studies of low molecular weight RNA from cells infected with adenovirus 2. II. Heterogeneity at the 5' end of VA-RNA I.

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