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PMID: 6264143 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Encephalomyocarditis viral RNA can be translated under conditions of poliovirus-induced translation shutoff in vivo.

Journal of virology ·Vol. 38 ·No. 2 ·1981-05-00 ·Pages 777-81

Detjen BM, Jen G, Thach RE

Abstract

Superinfection with poliovirus of HeLa cells already infected with encephalomyocarditis (EMC) virus does not inhibit translation of EMC viral mRNA, whereas residual host translation is completely inhibited. This result indicates that the cap recognition factors inactivated by poliovirus are not required for translation of EMC viral mRNA in vivo, in agreement with previous in vitro experiments. This raises the question of why EMC virus has evolved a capindependent translation mechanism.

MeSH Terms
Carrier Proteins/physiology Encephalomyocarditis virus/genetics,growth & development HeLa Cells Humans Poliovirus/physiology Protein Biosynthesis RNA Cap-Binding Proteins RNA Caps/physiology RNA, Messenger/genetics RNA, Viral/genetics Viral Proteins/biosynthesis Virus Replication
Chemicals
Carrier Proteins RNA Cap-Binding Proteins RNA Caps RNA, Messenger RNA, Viral Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Detjen B M
Jen G
Thach R E
References (20)
20 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.38.2.777-781.1981
Published
1981-05-00
Pages
777-81
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC171208
Subset
IM
Grants
NCI NIH HHS · CA-09129 · United States
NCI NIH HHS · CA-13008C · United States
NCI NIH HHS · P30 CA 16217 · United States
External Links
PubMed source DOI: 10.1128/JVI.38.2.777-781.1981 PMC Full Text View journal details
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