Zygotic induction of the rac locus can cause cell death in E. coli.
Conjugational transfer of the rac locus of E. coli K-12 into a Rac- recipient strain (i.e. rac+ X rac-) results in the killing of a majority of the recipient cells. The efficiency of killing depends somewhat on the plating medium, and can be as high as 98%. The killing is not observed in the rac+ X rac+, rac- X rac- or rac- X rac+ configurations. The rac locus, which has the properties of a cryptic prophage, may carry a function analogous to the kil function of bacteriophage lambda, or may instead cause killing by some replication related process.
18 references, click to expand
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Physical characterisation of the "Rac prophage" in E. coli K12.Mol Gen Genet. 1979 Sep;175(2):159-74 PMID: 390313
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Location and characterisation of a new replication origin in the E. coli K12 chromosome.Mol Gen Genet. 1979 Sep;175(2):151-7 PMID: 390312
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The origin of Q-independent derivatives of phage lambda.Mol Gen Genet. 1980;179(3):547-54 PMID: 6255285
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Genetic analysis of the RecE pathway of genetic recombination in Escherichia coli K-12.J Bacteriol. 1981 Jan;145(1):521-32 PMID: 6257642
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Effect of transient lambda prophage induction on ultraviolet light resistance and recombination in Escherichia coli.J Bacteriol. 1977 Jul;131(1):208-13 PMID: 326761
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Rac-E. coli K12 strains carry a preferential attachment site for lambda rev.Mol Gen Genet. 1981;183(3):484-9 PMID: 6460911
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On the nature of sbcA mutations in E. coli K 12.Mol Gen Genet. 1980;179(3):555-63 PMID: 6449653
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Characterization of the deoxyribonuclease determined by lambda reverse as exonuclease VIII of Escherichia coli.J Mol Biol. 1977 Jun 15;113(1):27-41 PMID: 328898
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Insertion of transposons through the major cotransduction gap of Escherichia coli K-12.J Bacteriol. 1982 Jan;149(1):106-13 PMID: 6274840
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Identification of a second cryptic lambdoid prophage locus in the E. coli K12 chromosome.Mol Gen Genet. 1980;180(2):479-81 PMID: 6258029
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Restoration by the rac locus of recombinant forming ability in recB - and recC - merozygotes of Escherichia coli K-12.Mol Gen Genet. 1973 Apr 12;122(2):119-30 PMID: 4573863
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The ral gene of phage lambda. I. Identification of a non-essential gene that modulates restriction and modification in E. coli.Mol Gen Genet. 1980;179(1):63-73 PMID: 6256607
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P1 transduction mapping of the trg locus in rac+ and rac strains of Escherichia coli K-12.J Bacteriol. 1982 Feb;149(2):529-33 PMID: 6276359
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P1 transduction map spanning the replication terminus of Escherichia coli K12.Mol Gen Genet. 1981;184(2):208-12 PMID: 6276692
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Isolation and properties of Tn10 insertions in the rac locus of Escherichia coli.Mol Gen Genet. 1981;183(2):333-40 PMID: 6276684
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Characterization of bacteriophage lambda reverse as an Escherichia coli phage carrying a unique set of host-derived recombination functions.J Mol Biol. 1974 Sep 15;88(2):471-87 PMID: 4616090
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The kil gene of bacteriophage lambda.Virology. 1975 Aug;66(2):589-604 PMID: 1098278
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Loss of rac locus DNA in merozygotes of Escherichia coli K12.Mol Gen Genet. 1979 Oct 1;175(3):245-50 PMID: 160489
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