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PMID: 6193915 Published · ppublish English Journal Article Review

The interferons.

Clinical and experimental immunology ·Vol. 54 ·No. 1 ·1983-10-00 ·Pages 1-13

Toy JL

Abstract

An overview of the interferons is presented. A description of something of what is known about them is given, including: their genes; their protein structures and characteristics; their mechanisms of actions; and their varied biological effects emphasising particularly their immunomodulatory actions. Finally, a brief summary is made of the current status of human clinical studies that have been conducted with interferons in the oncological and viral fields, mentioning also recent findings in patients who have the acquired immunodeficiency syndrome (AIDS).

MeSH Terms
Animals Antibodies, Monoclonal/immunology Humans Interferons/immunology,physiology,therapeutic use Lymphocytes/immunology Neoplasms/therapy
Chemicals
Antibodies, Monoclonal Interferons
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Toy J L
References (121)
121 references, click to expand
  1. Effect of interferon therapy on circulating lymphocytes in humans.
    J Interferon Res. 1980 Fall;1(1):101-10 PMID: 6180033
  2. Heterogeneity of human gamma interferon preparations: evidence for presence of alpha interferon.
    J Interferon Res. 1981 Feb;1(2):315-21 PMID: 6180062
  3. Multiple human beta interferon genes.
    J Exp Med. 1982 Sep 1;156(3):744-55 PMID: 6180119
  4. Structure of the human immune interferon gene.
    Nature. 1982 Aug 26;298(5877):859-63 PMID: 6180322
  5. Biochemistry of interferons and their actions.
    Annu Rev Biochem. 1982;51:251-82 PMID: 6180680
  6. Acid-labile human leukocyte interferon in homosexual men with Kaposi's sarcoma and lymphadenopathy.
    J Infect Dis. 1982 Oct;146(4):451-9 PMID: 7119475
  7. Effects of interferon-alpha on human warts.
    J Interferon Res. 1982;2(2):235-43 PMID: 7119508
  8. Human leukocyte interferon and cimetidine for metastatic melanoma.
    N Engl J Med. 1982 Oct 21;307(17):1080-1 PMID: 7121522
  9. Interferon-the first quarter century.
    JAMA. 1982 Nov 19;248(19):2513-6 PMID: 6182308
  10. Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells.
    Nature. 1982 Oct 28;299(5886):833-6 PMID: 6290893
  11. Renal cell carcinoma: antitumor effects of leukocyte interferon.
    Cancer Res. 1983 Feb;43(2):940-7 PMID: 6336662
  12. Tumor infiltrates in acquired immunodeficiency syndrome patients with Kaposi's sarcoma.
    Lancet. 1983 Feb 19;1(8321):416 PMID: 6130406
  13. A unique set of polypeptides is induced by gamma interferon in addition to those induced in common with alpha and beta interferons.
    Nature. 1983 Feb 3;301(5899):437-9 PMID: 6218412
  14. Interferon and laryngeal papillomatosis. The Iowa experience.
    Ann Otol Rhinol Laryngol. 1983 Jan-Feb;92(1 Pt 1):2-7 PMID: 6824274
  15. Interferon and cancer.
    Br Med J (Clin Res Ed). 1983 Mar 5;286(6367):739-40 PMID: 6186330
  16. Virus interference. I. The interferon.
    Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258-67 PMID: 13465720
  17. Stimulation of interferon production in human lymphocytes by mitogens.
    Proc Soc Exp Biol Med. 1967 Jul;125(3):901-5 PMID: 15938296
  18. Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome.
    Nature. 1977 May 12;267(5607):165-7 PMID: 16073432
  19. Interferon and murine leukemia. I. Inhibitory effect of interferon preparations on development of friend leukemia in mice.
    Proc Soc Exp Biol Med. 1967 Jan;124(1):84-91 PMID: 6017796
  20. Interferon and cell division. VI. Inhibitory effect of interferon on the multiplication of mouse embryo and mouse kidney cells in primary cultures.
    Proc Soc Exp Biol Med. 1971 Dec;138(3):1044-50 PMID: 5131604
  21. Interferon inhibits DNA synthesis induced in mouse lymphocyte suspensions by phytohaemagglutinin or by allogeneic cells.
    Nat New Biol. 1972 May 24;237(73):120-1 PMID: 4503851
  22. Some properties of virus and immune-induced human lymphocyte interferons.
    J Gen Virol. 1972 Aug;16(2):251-3 PMID: 5072368
  23. Effect of interferon and interferon inducers on the NK sensitivity of normal mouse thymocytes.
    J Immunol. 1980 Nov;125(5):2225-31 PMID: 6159402
  24. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.
    Nature. 1980 Oct 2;287(5781):401-8 PMID: 6159536
  25. A family of structural genes for human lymphoblastoid (leukocyte-type) interferon.
    Nature. 1980 Oct 2;287(5781):408-11 PMID: 6159537
  26. Human leukocyte interferon produced by E. coli is biologically active.
    Nature. 1980 Oct 2;287(5781):411-6 PMID: 6159538
  27. Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5437-40 PMID: 6159647
  28. Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma.
    Ann Intern Med. 1980 Sep;93(3):399-406 PMID: 6159812
  29. Interferon-induced resistance of fibroblasts to cytolysis mediated by natural killer cells: specificity and mechanism.
    J Immunol. 1981 Jan;126(1):335-40 PMID: 7451975
  30. Interferon induced in human leukocytes by mitogens: production, partial purification and characterization.
    Eur J Immunol. 1980 Nov;10(11):877-83 PMID: 6161829
  31. Augmentation of human K-cell activity with interferon.
    Scand J Immunol. 1980;12(5):365-9 PMID: 6162197
  32. The structure of eight distinct cloned human leukocyte interferon cDNAs.
    Nature. 1981 Mar 5;290(5801):20-6 PMID: 6163083
  33. Effect of type I and type II interferons on murine thymocyte surface antigen expression: induction or selection?
    Cell Immunol. 1981 Jan 15;57(2):427-39 PMID: 6163553
  34. Interferon therapy in juvenile laryngeal papillomatosis.
    Arch Otolaryngol. 1981 Jun;107(6):327-32 PMID: 6164359
  35. Changes in fatty acyl chains of phospholipids induced by interferon in mouse sarcoma S-180 cells.
    Biochem Biophys Res Commun. 1981 Feb 12;98(3):661-8 PMID: 6164365
  36. Interferon-induced augmentation of cytotoxic killer cell generation in mixed lymphocyte cultures: analysis of the effector cell product.
    Scand J Immunol. 1981;13(3):263-70 PMID: 6165076
  37. DNA sequence of two closely linked human leukocyte interferon genes.
    Science. 1981 Jun 5;212(4499):1159-62 PMID: 6165082
  38. Interaction of interferon, macrophage, and lymphocyte tumoricidal activity with prostaglandin effect.
    Ann N Y Acad Sci. 1980;350:91-101 PMID: 6165308
  39. Human tumor-lymphocyte interaction in vitro. VII. Blastogenesis and generation of cytotoxicity against autologous tumor biopsy cells are inhibited by interferon.
    Int J Cancer. 1980 Oct 15;26(4):405-11 PMID: 6166574
  40. Differential effect of interferon on the expression of tumor-associated antigens and histocompatibility antigens on human melanoma cells: relationship to susceptibility to immune lysis mediated by monoclonal antibodies.
    J Immunol. 1981 Aug;127(2):505-9 PMID: 6166672
  41. Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity.
    Proc Natl Acad Sci U S A. 1976 Oct;73(10):3695-9 PMID: 10573
  42. Membrane-bound interferon specific cell receptor system: role in the establishment and amplification of the antiviral state.
    Biomedicine. 1976 Jun;24(3):148-57 PMID: 136277
  43. A cell surface alteration in mouse L cells induced by interferon.
    Biochem Biophys Res Commun. 1977 Jan 24;74(2):707-13 PMID: 836320
  44. Differential effects of interferon on the expression of H-2K, H-2D, and Ia antigens on mouse lymphocytes.
    J Immunol. 1977 Feb;118(2):721-3 PMID: 839076
  45. Effects of interferon preparations on rabbit corneal xenograft.
    Arch Virol. 1977;53(1-2):157-61 PMID: 322645
  46. Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated with interferon.
    Proc Natl Acad Sci U S A. 1977 May;74(5):2036-40 PMID: 266723
  47. Stimulation of prostaglandin E production in cultured human fibroblasts by poly(I)-poly(C) and human interferon.
    Nature. 1977 Jun 2;267(5610):457-9 PMID: 876363
  48. Macrophage tumor killing: influence of the local environment.
    Science. 1977 Jul 15;197(4300):279-82 PMID: 327547
  49. Interferon: an inducer of macrophage activation by polyanions.
    Science. 1977 Aug 12;197(4304):674-6 PMID: 877584
  50. Functional and morphologic characteristics of interferon-treated macrophages.
    Cell Immunol. 1978 Jan;35(1):84-91 PMID: 620429
  51. Human leukocyte interferon for the treatment of herpes zoster in patients with cancer.
    N Engl J Med. 1978 May 4;298(18):981-7 PMID: 347294
  52. Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins.
    J Immunol. 1978 Jun;120(6):1849-55 PMID: 659880
  53. Suppressor cells in neoplastic disease.
    J Natl Cancer Inst. 1978 Jul;61(1):5-11 PMID: 353295
  54. Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth.
    Nature. 1978 Aug 24;274(5673):798-800 PMID: 683317
  55. Relationships of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state.
    Cancer Res. 1978 Nov;38(11 Pt 2):4172-85 PMID: 212189
  56. Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody-dependent cellular cytotoxicity: differential sensitivity of effector cells to in vivo and in vitro corticosteroids.
    Scand J Immunol. 1978;8(2):99-107 PMID: 705262
  57. Antitumor effects of interferon.
    Biochim Biophys Acta. 1978 Oct 27;516(2):231-47 PMID: 365241
  58. Interferon and spontaneous cytotoxicity in man. II. Studies in patients receiving exogenous leukocyte interferon.
    Acta Med Scand. 1978;204(6):477-83 PMID: 282781
  59. The use of the chemostat to study the relationship between cell growth rate, viability, and the effect of interferon on L 1210 cells.
    Exp Cell Res. 1979 Feb;118(2):383-8 PMID: 367800
  60. Natural killer cells: characteristics and regulation of activity.
    Immunol Rev. 1979;44:43-70 PMID: 761939
  61. Selective inhibition by interferon of serum-stimulated biochemical events in 3T3 cells.
    Biochem Biophys Res Commun. 1979 Apr 13;87(3):679-85 PMID: 454417
  62. Human leucocyte interferon: analysis of effect on MLC and effector cell generation.
    Scand J Immunol. 1979;9(6):517-26 PMID: 156947
  63. Enhanced expression of HLA antigens and beta 2-microglobulin on interferon-treated human lymphoid cells.
    Eur J Immunol. 1979 Jun;9(6):446-9 PMID: 91516
  64. Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis.
    Lancet. 1980 Feb 16;1(8164):336-8 PMID: 6101791
  65. Relationship between enhanced macrophage phagocytic activity and the induction of interferon by Newcastle disease virus in mice.
    J Immunol. 1980 Mar;124(3):1360-4 PMID: 6965692
  66. Interferon as a mediator of human lymphocyte suppression.
    J Exp Med. 1980 Mar 1;151(3):637-50 PMID: 6444662
  67. Host genotype influences immunomodulation by interferon.
    Nature. 1980 Mar 13;284(5752):173-5 PMID: 7360243
  68. Nonsteroidal compounds which bind epididymal androgen-binding protein but not the androgen receptor.
    Nature. 1980 Apr 3;284(5755):458-9 PMID: 6965770
  69. Double-stranded RNA inhibits a phosphoprotein phosphatase present in interferon-treated cells.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):107-11 PMID: 6244537
  70. Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts.
    J Cell Biol. 1980 Apr;85(1):9-17 PMID: 6154057
  71. Modulation of target cell susceptibility to human natural killer cells by interferon.
    Int J Cancer. 1980 May 15;25(5):565-72 PMID: 6154661
  72. Differential effect of interferon expression of IgG- and IgM-Fc receptors on human lymphocytes.
    J Immunol. 1980 Jun;124(6):2589-95 PMID: 6154733
  73. Inhibition of murine natural killer cell activity by prostaglandins.
    J Immunol. 1980 Jun;124(6):2682-7 PMID: 6154736
  74. Augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo.
    J Exp Med. 1980 Apr 1;151(4):781-9 PMID: 6154760
  75. Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphcoytes.
    J Exp Med. 1980 May 1;151(5):1151-65 PMID: 6154767
  76. Role of G0-G1 arrest in the inhibition of tumor cell growth by interferon.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1471-5 PMID: 6154934
  77. Virus and interferon effects on cellular prostaglandin biosynthesis.
    J Immunol. 1980 Jul;125(1):431-7 PMID: 6155405
  78. Mode of action of interferon-mediated modulation of natural killer cytotoxic activity: recruitment of pre-NK cells and enhanced kinetics of lysis.
    J Immunol. 1980 Aug;125(2):479-84 PMID: 6156205
  79. Arylsulphatase activity in liver and gastrointestinal tract of sheep [proceedings].
    Biochem Soc Trans. 1980 Jun;8(3):343-4 PMID: 7399086
  80. Enhancement of phagocytosis by interferon-containing preparations.
    Infect Immun. 1971 Nov;4(5):581-8 PMID: 4343410
  81. Interferon preparations as modifiers of immune responses.
    Proc Soc Exp Biol Med. 1972 Dec;141(3):769-73 PMID: 4566752
  82. Inhibition of respiratory virus infection by locally applied interferon.
    Lancet. 1973 Mar 17;1(7803):563-7 PMID: 4120640
  83. Clinical and laboratory investigations on man: systemic administration of potent interferon to man.
    J Natl Cancer Inst. 1973 Sep;51(3):733-42 PMID: 4355215
  84. Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin.
    J Natl Cancer Inst. 1974 Feb;52(2):553-9 PMID: 4856157
  85. [Prolongation, by interferon, of the survival of skin grafts in the mouse].
    C R Acad Sci Hebd Seances Acad Sci D. 1973 Nov 12;277(19):2101-3 PMID: 4208698
  86. Administration of human leukocyte interferon in herpes zoster. I. Safety, circulating, antiviral activity, and host responses to infection.
    J Infect Dis. 1974 Jul;130(1):56-62 PMID: 4601181
  87. Effects of interferon on antibody synthesis in vitro.
    J Immunol. 1974 Aug;113(2):438-44 PMID: 4602660
  88. Binding of interferon to gangliosides.
    Nature. 1974 Dec 6;252(5483):478-80 PMID: 4372547
  89. Inhibition of steroid inducible tyrosine aminotransferase by mouse and rat interferon in hepatoma tissue culture cells.
    FEBS Lett. 1974 Nov 15;48(2):297-300 PMID: 4154871
  90. Phagocytosis-enhancing effect of human leukocyte interferon preparation of human peripheral monocytes in vitro.
    Acta Virol. 1975 Jan;19(1):52-8 PMID: 235198
  91. Fluorescence-activated cell sorting of human T and B lymphocytes. II. Identification of the cell type responsible for interferon production and cell proliferation in response to mitogens.
    Cell Immunol. 1974 Jun;12(3):407-21 PMID: 4617634
  92. Inhibition by interferon of delayed-type hypersensitivity in the mouse.
    Proc Natl Acad Sci U S A. 1975 May;72(5):1753-7 PMID: 168573
  93. Delayed-type hypersensitivity to sheep red blood cells: inhibition of sensitization by interferon.
    Science. 1975 Nov 7;190(4214):574-6 PMID: 1188355
  94. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  95. Localization fo the gene AVG for the antiviral expression of immune and classical interferon to the distal portion of the long arm of chromosome 21.
    J Infect Dis. 1976 Jun;133 Suppl:A56-62 PMID: 180211
  96. The nature of the suppressive effect of interferon and interferon inducers on the in vitro immune response.
    Cell Immunol. 1976 Jul;25(1):106-15 PMID: 786465
  97. Regulatory effect of interferon on T cells in vitro.
    J Immunol. 1976 Oct;117(4):1370-3 PMID: 135810
  98. Interferon inhibits the redistribution of cell surface components.
    J Exp Med. 1980 Aug 1;152(2):469-74 PMID: 6156989
  99. A monoclonal antibody for large-scale purification of human leukocyte interferon.
    Nature. 1980 Jun 12;285(5765):446-50 PMID: 6157091
  100. Isolation and structure of a human fibroblast interferon gene.
    Nature. 1980 Jun 19;285(5766):542-7 PMID: 6157094
  101. Human leukocyte and fibroblast interferons are structurally related.
    Nature. 1980 Jun 19;285(5766):547-9 PMID: 6157095
  102. At least three human type alpha interferons: structure of alpha 2.
    Science. 1980 Sep 19;209(4463):1343-7 PMID: 6158094
  103. Augmentation of human monocyte-mediated cytolysis by interferon.
    Cell Immunol. 1980 Sep 1;54(2):425-34 PMID: 6158375
  104. Effect of virus-induced interferon on the antibody response of suckling and adult mice.
    Eur J Immunol. 1980 Oct;10(10):767-72 PMID: 6159214
  105. Leukocyte and fibroblast interferon genes are located on human chromosome 9.
    Proc Natl Acad Sci U S A. 1981 May;78(5):3123-7 PMID: 6166943
  106. Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells.
    J Immunol. 1981 Sep;127(3):1197-200 PMID: 6167620
  107. Antiviral treatment of chronic hepatitis B virus infection: improvement in liver disease with interferon and adenine arabinoside.
    Hepatology. 1981 May-Jun;1(3):228-32 PMID: 6169615
  108. Interferon acts directly on human B lymphocytes to modulate immunoglobulin synthesis.
    J Immunol. 1981 Nov;127(5):2146-50 PMID: 6170691
  109. Opportunistic infections and Kaposi's sarcoma in homosexual men.
    N Engl J Med. 1981 Dec 10;305(24):1465-7 PMID: 6272112
  110. Reversibility of the transformed and neoplastic phenotype. I. Progressive reversion of the phenotype of X-ray-transformed C3H/10T1/2 cells under prolonged treatment with interferon.
    Int J Cancer. 1981 Aug 15;28(2):165-73 PMID: 6172389
  111. The clinical value of interferons as antitumor agents.
    Eur J Cancer Clin Oncol. 1981 Sep;17(9):949-67 PMID: 6173223
  112. Purification and characterization of human interferon from lymphoblastoid (Namalva) cultures.
    Methods Enzymol. 1981;78(Pt A):457-64 PMID: 6173629
  113. Human leukocyte interferon for the treatment of varicella in children with cancer.
    N Engl J Med. 1982 Apr 1;306(13):761-5 PMID: 6174864
  114. Monoclonal antibody against human IFN-gamma.
    Nature. 1982 Mar 18;296(5854):258-9 PMID: 6174871
  115. A rat monoclonal antibody against mouse alpha and beta interferon of all molecular weight species.
    Nature. 1982 Apr 15;296(5858):664-5 PMID: 6175905
  116. Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.
    Science. 1982 Apr 23;216(4544):429-31 PMID: 6176024
  117. Interferon inhibits the generation of allospecific suppressor T lymphocytes.
    J Exp Med. 1982 Jun 1;155(6):1610-22 PMID: 6176663
  118. Purification of two subspecies of human gamma (immune) interferon.
    Proc Natl Acad Sci U S A. 1982 Mar;79(6):1820-4 PMID: 6177002
  119. Purified interferon as protection against rhinovirus infection.
    Br Med J (Clin Res Ed). 1982 Jun 19;284(6332):1822-5 PMID: 6177374
  120. Leukocyte-derived interferon (alpha) in human breast carcinoma. The American Cancer Society phase II trial.
    Ann Intern Med. 1982 Jul;97(1):1-6 PMID: 6178335
  121. Mechanism of stimulation by human interferon of prostaglandin synthesis in human cell lines.
    Cancer Res. 1982 Aug;42(8):3209-14 PMID: 6178505
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1983-10-00
Pages
1-13
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1536188
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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