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PMID: 6101791 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis.

Lancet (London, England) ·Vol. 1 ·No. 8164 ·1980-02-16 ·Pages 336-8

Weimar W, Heijtink RA, ten Kate FJ, Schalm SW, Masurel N, Schellekens H, Cantell K

Abstract

In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12 x 10(6) reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection.

MeSH Terms

Adult Cell Extracts/administration & dosage Clinical Trials as Topic DNA-Directed DNA Polymerase/metabolism Female Hepatitis B/enzymology,therapy Humans Injections, Intramuscular Interferons/administration & dosage,adverse effects Leukocytes Leukopenia/etiology Male Middle Aged Nucleic Acid Synthesis Inhibitors Research Design Time Factors

Chemicals

Cell Extracts Nucleic Acid Synthesis Inhibitors Interferons DNA-Directed DNA Polymerase

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Weimar W

Heijtink R A

ten Kate F J

Schalm S W

Masurel N

Schellekens H

Cantell K

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(80)90885-5

Published

1980-02-16

Pages

336-8

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(80)90885-5 View journal details

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Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis.

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