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PMID: 6175576 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Different effects of influenza virus, respiratory syncytial virus, and Sendai virus on human lymphocytes and macrophages.

Infection and immunity ·Vol. 35 ·No. 3 ·1982-03-00 ·Pages 1142-6

Roberts NJ

Abstract

Influenza virus, respiratory syncytial virus, and Sendai virus depress human cell-mediated immune responses, such as mitogen-induced lymphocyte transformation, but differ in their ability to induce other immune defense mechanisms, such as interferon production. Exposure to the different viruses resulted in depressed transformation responses to the mitogen phytohemagglutinin by affecting the function of lymphocytes, or macrophages, or both cell types.

MeSH Terms
Adult Female Humans Influenza A virus/physiology Interferons/biosynthesis Lymphocyte Activation Lymphocytes/immunology Macrophages/immunology Male Parainfluenza Virus 1, Human/physiology Phytohemagglutinins/pharmacology Respiratory Syncytial Viruses/physiology
Chemicals
Phytohemagglutinins Interferons
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Roberts N J
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26 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.35.3.1142-1146.1982
Published
1982-03-00
Pages
1142-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC351166
Subset
IM
Grants
NIAID NIH HHS · AI 15547 · United States
External Links
PubMed source DOI: 10.1128/iai.35.3.1142-1146.1982 PMC Full Text View journal details
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