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PMID: 6163726 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses.

Infection and immunity ·Vol. 32 ·No. 1 ·1981-04-00 ·Pages 300-3

Chonmaitree T, Roberts NJ, Douglas RG, Hall CB, Simons RL

Abstract

The ability of respiratory syncytial virus (RSV) to induce interferon production by human mononuclear leukocytes was compared with that of influenza viruses. Cell culture fluids were assayed for interferon activity 1, 3 and 7 days after exposure to RSV or to one of two subtypes of influenza A virus (H0N1 and H3N2). RSV induced interferon production inconsistently and in low titers. Varying the multiplicity of infection did not improve the ability of RSV to induce interferon production. In contrast, influenza viruses were effective inducers of interferon production. Seropositivity to the influenza virus strains was not associated with increased interferon titers. Interferon produced after exposure to RSV or to the influenza viruses was resistant to low pH treatment. The data suggest that interferon production may not be a major component of human immunological defense against RSV infection.

MeSH Terms
Adult Female Humans Hydrogen-Ion Concentration Influenza A virus/immunology Interferon Inducers/pharmacology Interferons/biosynthesis Male Phagocytes/immunology Respiratory Syncytial Viruses/immunology
Chemicals
Interferon Inducers Interferons
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Chonmaitree T
Roberts N J
Douglas R G
Hall C B
Simons R L
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.32.1.300-303.1981
Published
1981-04-00
Pages
300-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC350621
Subset
IM
Grants
NIAID NIH HHS · AI-07137-04 · United States
NIAID NIH HHS · AI-15547 · United States
External Links
PubMed source DOI: 10.1128/iai.32.1.300-303.1981 PMC Full Text View journal details
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