Replication or inactivation of different viruses by human lymphocyte preparations.

Infection and immunity ·Vol. 9 ·No. 2 ·1974-02-00 ·Pages 373-6

Denman AM, Rager-Zisman B, Merigan TC, Tyrrell DA

Abstract

Cultures of phytohemagglutinin-stimulated, unstimulated, and frozen and thawed mononuclear (as controls) cells from normal human donors were infected with different viruses. A variable pattern of virus infectivity was noted, and influenza and Coxsackie virus were rapidly inactivated even by stimulated lymphocytes. Direct inactivation by lymphocytes may be one form of host defense in infection by some viruses.

MeSH Terms

Adenoviridae/immunology Adult Antibodies, Viral/analysis Carbon Radioisotopes Cells, Cultured DNA/metabolism Enterovirus/immunology Enterovirus B, Human/immunology Freezing Humans Lectins/pharmacology Lymphocytes/drug effects,immunology,metabolism Male Measles virus/immunology Orthomyxoviridae/immunology Simplexvirus/immunology Thymidine/metabolism Time Factors Vesicular stomatitis Indiana virus/immunology Virus Replication Yellow fever virus/immunology

Chemicals

Antibodies, Viral Carbon Radioisotopes Lectins DNA Thymidine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Denman A M

Rager-Zisman B

Merigan T C

Tyrrell D A

References (14)

14 references, click to expand

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Vaccinia virus replication and cytopathic effect in cultures in phytohemagglutinin-treated human peripheral blood leukocytes.
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Antigen-binding lymphocytes in human blood.
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Specific role of each human leukocyte type in viral infections. I. Monocyte as host cell for vesicular stomatitis virus replication in vitro.
J Virol. 1967 Dec;1(6):1139-49 PMID: 4316248
Lymphocytes and yellow fever. I. Transient virus refractory state following vaccination of man with the 17-D strain.
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A plaque assay for enumerating antigen-sensitive cells in delayed-type hypersensitivity.
J Exp Med. 1970 Jul 1;132(1):16-30 PMID: 4323747
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Proc Natl Acad Sci U S A. 1972 Sep;69(9):2632-6 PMID: 4506785
Virus-induced alterations of lymphoid tissues. II. Lymphocyte receptors for Newcastle disease virus.
Cell Immunol. 1972 Oct;5(2):296-306 PMID: 4627319
Herpes simplex virus replication in human lymphocyte cultures stimulated with phytomitogens and anti-lymphocyte globulin.
Proc Soc Exp Biol Med. 1972 Dec;141(3):1095-9 PMID: 4345704
A useful quantitative semimicromethod for viral plaque assay.
Proc Soc Exp Biol Med. 1973 Apr;142(4):1174-9 PMID: 4121080
Review: method of separating human blood lymphoid cell populations.
J Immunol Methods. 1973 Jun;2(4):331-51 PMID: 4269268
VIRAL LEUKOCYTE INTERRELATIONSHIPS. I. MULTIPLICATION OF A DNA VIRUS--HERPES SIMPLEX--IN HUMAN LEUKOCYTE CULTURES.
J Immunol. 1964 Jul;93:69-74 PMID: 14214391
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.9.2.373-376.1974

Published

1974-02-00

Pages

373-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414811

Subset

External Links

PubMed source DOI: 10.1128/iai.9.2.373-376.1974 PMC Full Text View journal details

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Replication or inactivation of different viruses by human lymphocyte preparations.

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