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PMID: 6140268 Published · ppublish English Journal Article Review

Regulation of the immune response by prostaglandins.

Journal of clinical immunology ·Vol. 3 ·No. 4 ·1983-10-00 ·Pages 295-315

Goodwin JS, Ceuppens J

Abstract

Of all the arachidonic acid metabolites, only prostaglandin E (PGE) has been shown to have a clear role in the regulation of cellular and humoral immune responses. In cellular immune responses such as T cell proliferation, lymphokine production, and cytotoxicity, PGE usually acts as a feedback inhibitor of the response. This is also true of macrophage and natural killer cytotoxicity. In some instances PGE is responsible for cellular activation rather than inhibition. This is clearest in the control of humoral immunity, where PGE production is a necessary component in the generation of some type of T suppressor cells. Disturbances in immune function found in several human conditions and diseases have been linked to changes in PGE mediated immunoregulation. Either increased production of PGE or increased sensitivity to PGE results in depressed cellular immunity. Conversely drugs which inhibit PGE production act as stimulants of cellular immune function in vitro and in vivo.

MeSH Terms
Adult Aged Animals Antibody Formation Autoantibodies/biosynthesis Cattle Cell Transformation, Neoplastic/immunology Cyclooxygenase Inhibitors Dinoprostone Feedback Guinea Pigs Humans Hypersensitivity, Delayed/immunology Immunity, Cellular Indomethacin/administration & dosage Lymphocyte Activation Lymphocytes/immunology,physiology Mice Prostaglandin Antagonists/administration & dosage Prostaglandins E/biosynthesis,metabolism,physiology Receptors, Prostaglandin/analysis Receptors, Prostaglandin E T-Lymphocytes, Helper-Inducer/immunology T-Lymphocytes, Regulatory/immunology
Chemicals
Autoantibodies Cyclooxygenase Inhibitors Prostaglandin Antagonists Prostaglandins E Receptors, Prostaglandin Receptors, Prostaglandin E Dinoprostone Indomethacin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goodwin J S
Ceuppens J
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00915791
Published
1983-10-00
Pages
295-315
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00915791 View journal details
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