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PMID: 370015 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Adjuvants in the induction of suppressor cells.

Infection and immunity ·Vol. 23 ·No. 2 ·1979-02-00 ·Pages 360-5

Neta R, Salvin SB

Abstract

The effect of different mycobacterial adjuvants on the parameters of delayed hypersensitivity was investigated in strain 13 guinea pigs. The composition of the tubercle bacilli and the type of vehicle in which the antigen was presented determined the presence and extent of suppressor cell activity. When antigen was introduced in complete Freund adjuvant, both adherent and nonadherent cells had suppressive properties, with the suppressive effect demonstrable in vitro from 1 to 5 weeks after sensitization. Suppressor activity was indicated in vivo by a reduction of delayed footpad hypersensitivity in animals presensitized with complete Freund adjuvant.

MeSH Terms
Adjuvants, Immunologic/pharmacology Animals Antigens, Bacterial BCG Vaccine Cell Division Guinea Pigs Hypersensitivity, Delayed Macrophage Migration-Inhibitory Factors/biosynthesis Macrophages/immunology Mycobacterium bovis/immunology T-Lymphocytes/immunology
Chemicals
Adjuvants, Immunologic Antigens, Bacterial BCG Vaccine Macrophage Migration-Inhibitory Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Neta R
Salvin S B
References (18)
18 references, click to expand
  1. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.
    J Exp Med. 1964 Jul 1;120:105-20 PMID: 14194388
  2. Impairment of immunological reactivity in guinea pigs by prior injection of adjuvant.
    Nature. 1962 Feb 24;193:789-90 PMID: 14451147
  3. T and B lymphocytes in the regulation of delayed hypersensitivity.
    J Immunol. 1976 Nov;117(5 Pt.2):2014-20 PMID: 62803
  4. The effect of cyclophosphamide on suppressor cells in guinea pigs.
    Cell Immunol. 1977 Oct;33(2):402-11 PMID: 303149
  5. Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients.
    J Immunol. 1973 May;110(5):1290-9 PMID: 4121422
  6. Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. II. Mechanism of the phenomenon.
    Clin Exp Immunol. 1971 Aug;9(2):259-66 PMID: 4105804
  7. Immunological enhancement: a study of blocking antibodies.
    Adv Immunol. 1972;15:167-214 PMID: 4404339
  8. Regulation of the antibody response to type 3 pneumococcal polysaccharide. II. Mode of action of thymic-derived suppressor cells.
    J Immunol. 1974 Jan;112(1):404-9 PMID: 4149590
  9. Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis.
    J Immunol. 1975 Sep;115(3):631-3 PMID: 50370
  10. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity.
    J Immunol. 1974 Dec;113(6):1716-25 PMID: 4279260
  11. T cell control of antibody production.
    Contemp Top Immunobiol. 1974;3:1-40 PMID: 4598645
  12. A possible relationship between delayed hypersensitivity and cell-mediated immunity.
    Am Rev Respir Dis. 1975 Apr;111(4):373-7 PMID: 47728
  13. Specific depression of delayed hypersensitivity to purified proteins, with relation to production of circulating antibody.
    Cell Immunol. 1973 Nov;9(2):242-50 PMID: 4752846
  14. Communications. "In vitro" cell reactions in delayed hypersensitivity.
    J Immunol. 1969 Jul;103(1):138-41 PMID: 4978776
  15. Migration inhibitory factor and type II interferon in the circulation of mice sensitized with mycobacterial components.
    J Immunol. 1975 Jan;114(1 Pt 2):354-9 PMID: 1090652
  16. Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts.
    J Immunol. 1976 Mar;116(3):791-9 PMID: 1082894
  17. Adjuvant regulation of T cell function.
    J Immunol. 1976 Mar;116(3):710-5 PMID: 1082892
  18. Altered lymphocyte functions in rats bearing syngeneic Moloney sarcoma tumors. II. Suppressor cells.
    J Immunol. 1976 Aug;117(2):655-60 PMID: 950466
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.23.2.360-365.1979
Published
1979-02-00
Pages
360-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414173
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.23.2.360-365.1979 PMC Full Text View journal details
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