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PMID: 6098460 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Tracts of high or low sequence divergence in the mouse major histocompatibility complex.

The EMBO journal ·Vol. 3 ·No. 12 ·1984-12-01 ·Pages 2995-3003

Steinmetz M, Malissen M, Hood L, Orn A, Maki RA, Dastoornikoo GR, Stephan D, Gibb E, Romaniuk R

Abstract

The K, I and S regions of the mouse major histocompatibility complex (MHC) are composed of long tracts of DNA which differ in sequence divergence. A correlation exists between the location of an MHC gene in a variable or conserved chromosomal tract and the degree of polymorphism and diversity of the proteins encoded by its alleles. Variable tracts appear to be the result of mechanisms which mutate certain coding and non-coding sequences to the same extent and selective pressures operating on the genes.

MeSH Terms
Animals Base Sequence Biological Evolution Cloning, Molecular DNA Restriction Enzymes Genetic Variation Major Histocompatibility Complex Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred Strains Nucleic Acid Hybridization Plasmids Polymorphism, Genetic Species Specificity
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Steinmetz M
Malissen M
Hood L
Orn A
Maki R A
Dastoornikoo G R
Stephan D
Gibb E
Romaniuk R
References (56)
56 references, click to expand
  1. Clusters of genes encoding mouse transplantation antigens.
    Cell. 1982 Mar;28(3):489-98 PMID: 6280871
  2. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain.
    Cell. 1982 Mar;28(3):499-506 PMID: 6804095
  3. Isolation of transforming DNA by cosmid rescue.
    Proc Natl Acad Sci U S A. 1982 Jan;79(2):520-4 PMID: 6210908
  4. Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):2194-8 PMID: 6326111
  5. Expression of hemolytically active murine fourth component of complement in transfected L cells.
    Cell. 1984 Jun;37(2):569-76 PMID: 6327077
  6. Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone.
    EMBO J. 1984 Apr;3(4):873-7 PMID: 6327293
  7. Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types.
    Proc Natl Acad Sci U S A. 1984 Jun;81(11):3461-5 PMID: 6328517
  8. The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans.
    Cell. 1984 Jul;37(3):1091-9 PMID: 6331676
  9. The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex.
    EMBO J. 1984 Jun;3(6):1221-5 PMID: 6086309
  10. Eo: a history of a mutation.
    EMBO J. 1984 Jul;3(7):1647-54 PMID: 6745246
  11. Mutations and selection in the generation of class II histocompatibility antigen polymorphism.
    EMBO J. 1984 Jul;3(7):1655-61 PMID: 6589154
  12. Cytolytic T cells recognize the two amino-terminal domains of H-2 K antigens in tandem in influenza A infected cells.
    Cell. 1984 Aug;38(1):79-87 PMID: 6088078
  13. Genes of the major histocompatibility complex of the mouse.
    Annu Rev Immunol. 1983;1:529-68 PMID: 6152713
  14. Molecular characterization of the recombination region of six murine major histocompatibility complex (MHC) I-region recombinants.
    J Mol Cell Immunol. 1984;1(2):125-35 PMID: 6152893
  15. Polymorphism of germ-line immunoglobulin VH genes correlates with allotype and idiotype markers.
    Eur J Immunol. 1981 Dec;11(12):1017-20 PMID: 6276186
  16. Mouse histocompatibility genes: structure and organisation of a Kd gene.
    EMBO J. 1983;2(2):245-54 PMID: 11894934
  17. The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.
    EMBO J. 1983;2(3):453-62 PMID: 11894963
  18. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.
    Proc Natl Acad Sci U S A. 1978 Nov;75(11):5631-5 PMID: 281713
  19. Mathematical model for studying genetic variation in terms of restriction endonucleases.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):5269-73 PMID: 291943
  20. Immunochemical evidence in two haplotypes for at least three D region-encoded molecules, D, L, and R.
    J Immunol. 1981 May;126(5):1713-6 PMID: 7217662
  21. Rapid and efficient cosmid cloning.
    Nucleic Acids Res. 1981 Jul 10;9(13):2989-98 PMID: 6269067
  22. Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.
    Proc Natl Acad Sci U S A. 1981 Jul;78(7):4495-9 PMID: 6170065
  23. Polymorphism of the mouse H-2 loci.
    Immunol Rev. 1981;60:23-57 PMID: 7030925
  24. The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse.
    J Biol Chem. 1982 Jan 10;257(1):277-85 PMID: 6273429
  25. Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes.
    Nature. 1982 Aug 5;298(5874):529-34 PMID: 6285197
  26. Structure of wild-type and mutant mouse beta 2-microglobulin genes.
    Cell. 1982 Jun;29(2):661-9 PMID: 6180834
  27. Primary structure of the H-2Db alloantigen. II. Additional amino acid sequence information, localization of a third site of glycosylation and evidence for K and D region specific sequences.
    Immunogenetics. 1982;16(1):11-22 PMID: 7118212
  28. Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer.
    Nature. 1982 Nov 18;300(5889):231-7 PMID: 6815535
  29. Allelic polymorphism and complexity of the genes for HLA-DR beta-chains--direct analysis by DNA-DNA hybridization.
    Nature. 1982 Nov 25;300(5890):372-4 PMID: 6292729
  30. DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse.
    Science. 1982 Dec 17;218(4578):1229-32 PMID: 6815800
  31. The construction of cosmid libraries which can be used to transform eukaryotic cells.
    Nucleic Acids Res. 1982 Nov 11;10(21):6715-32 PMID: 6294612
  32. Cloning of a human complement component C4 gene.
    Proc Natl Acad Sci U S A. 1983 Jan;80(1):264-7 PMID: 6572000
  33. Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.
    Cell. 1983 Feb;32(2):515-23 PMID: 6297797
  34. The murine E alpha immune response gene.
    Cell. 1983 Mar;32(3):745-54 PMID: 6403249
  35. Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1972-6 PMID: 6300884
  36. Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex.
    Proc Natl Acad Sci U S A. 1983 Jun;80(11):3425-9 PMID: 6304710
  37. Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes.
    Science. 1983 Jul 15;221(4607):283-6 PMID: 6407114
  38. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex.
    Immunogenetics. 1983;17(6):553-96 PMID: 6407984
  39. The complete nucleotide sequence of the I-E alpha d immune response gene.
    Nucleic Acids Res. 1983 Aug 11;11(15):5055-71 PMID: 6308570
  40. Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d.
    Science. 1983 Aug 19;221(4612):750-4 PMID: 6410508
  41. Regions of allelic hypervariability in the murine A alpha immune response gene.
    Cell. 1983 Aug;34(1):169-77 PMID: 6309407
  42. Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon.
    Cell. 1983 Aug;34(1):179-88 PMID: 6411350
  43. RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex.
    Proc Natl Acad Sci U S A. 1983 Sep;80(18):5704-8 PMID: 6193520
  44. Extensive polymorphism surrounding the murine Ia A beta chain gene.
    J Immunol. 1983 Oct;131(4):2025-31 PMID: 6311906
  45. Genes of the major histocompatibility complex in mouse and man.
    Science. 1983 Nov 18;222(4625):727-33 PMID: 6356354
  46. Polymorphism and diversity in the Tla gene system.
    Immunogenetics. 1983;18(5):445-51 PMID: 6642572
  47. Molecular map of the murine S region.
    Proc Natl Acad Sci U S A. 1983 Nov;80(22):6947-51 PMID: 6316336
  48. A potential donor gene for the bm1 gene conversion event in the C57BL mouse.
    Nature. 1983 Dec 22-1984 Jan 4;306(5945):792-5 PMID: 6656881
  49. The class II molecules of the human and murine major histocompatibility complex.
    Cell. 1984 Jan;36(1):1-13 PMID: 6198089
  50. Restriction sites containing CpG show a higher frequency of polymorphism in human DNA.
    Cell. 1984 Jan;36(1):131-8 PMID: 6198090
  51. A nonpolymorphic class I gene in the murine major histocompatibility complex.
    Cell. 1984 Jan;36(1):139-44 PMID: 6420070
  52. A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.
    Nature. 1984 Jan 19-25;307(5948):237-41 PMID: 6559257
  53. Chromosome 4 Jt gene controls murine T cell surface I-J expression.
    Science. 1984 Feb 10;223(4636):559-63 PMID: 6607530
  54. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins.
    Nature. 1984 Mar 8-14;308(5955):153-8 PMID: 6546606
  55. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.
    Nature. 1984 Mar 22-28;308(5957):327-33 PMID: 6584734
  56. The biochemical genetics of the Qa-Tla region.
    Transplant Proc. 1983 Dec;15(4):2033-8 PMID: 6673205
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-12-01
Pages
2995-3003
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557803
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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