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PMID: 6098459 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Structure and polymorphism of the HLA class II SB light chain genes.

The EMBO journal ·Vol. 3 ·No. 12 ·1984-12-01 ·Pages 2985-93

Kappes DJ, Arnot D, Okada K, Strominger JL

Abstract

The HLA Class II region contains at least three groups of loci, DR, DC and SB, which play an important role in the immune response. The antigens encoded at these loci are heterodimers composed of an alpha and a beta chain. The sequence of a complete Class II beta cDNA clone whose sequence agrees closely with the limited N-terminal protein sequence available for the SB beta chain is reported. In addition the structure and coding sequence of genomic SB beta clones of two different SB haplotypes has been obtained and allows definition of some polymorphic regions. The SB beta gene appears to undergo alternate splicing at its 3' end, resulting in expression of two different intracytoplasmic regions. Partial sequencing of a second non-allelic SB beta-like gene, SX beta, indicates that it is a pseudogene.

MeSH Terms
Amino Acid Sequence B-Lymphocytes/immunology Base Sequence Cell Line Cloning, Molecular DNA/isolation & purification DNA Restriction Enzymes Genes Genes, MHC Class II HLA Antigens/genetics Humans Immunoglobulin Light Chains/genetics Polymorphism, Genetic Transcription, Genetic
Chemicals
HLA Antigens Immunoglobulin Light Chains DNA DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kappes D J
Arnot D
Okada K
Strominger J L
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22 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-12-01
Pages
2985-93
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557802
Subset
IM
Grants
NIADDK NIH HHS · AM-30241 · United States
Databases
GENBANK
X01426, X02964, X03022, X03023, X03024, X03025, X03026, X03027, X03028
External Links
PubMed source PMC Full Text View journal details
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