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PMID: 6095198 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A novel transposon-like repeat interrupted by an LTR element occurs in a cluster of B1 repeats in the mouse c-mos locus.

Nucleic acids research ·Vol. 12 ·No. 22 ·1984-11-26 ·Pages 8381-92

Propst F, Vande Woude GF

Abstract

The mouse genomic locus containing the oncogene c-mos was analyzed for repetitive DNA sequences. We found a single B1 repeat 10 kb upstream and three B1 repeats 0.6 kb, 2.7 kb, and 5.4 kb, respectively, downstream from c-mos. The B1 repeat closest to c-mos contains an internal 7-bp duplication and a 18-bp insertion. Localized between the last two B1 repeats is a copy of a novel mouse repeat. Sequence comparison of three copies of this novel repeat family shows that they a) contain a conserved BglII site, b) are approximately 420 bp long, c) possess internal 50-bp polypurine tracts, and d) have structural characteristics of transposable elements. They are present in about 1500 copies per haploid genome in the mouse, but are not detectable in DNA of other mammals. The BglII repeat downstream from c-mos is interrupted by a single 632-bp LTR element. We estimate that approximately 1200 copies of this element are present per haploid genome in BALB/c mice. It shares sequence homology in the R-U5 region with an LTR element found in 129/J mice.

MeSH Terms
Animals Base Sequence Cloning, Molecular DNA Restriction Enzymes DNA Transposable Elements Mice Nucleic Acid Hybridization Oncogenes Repetitive Sequences, Nucleic Acid
Chemicals
DNA Transposable Elements DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Propst F
Vande Woude G F
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28 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.22.8381
Published
1984-11-26
Pages
8381-92
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320374
Subset
IM
Grants
PHS HHS · N01-C0-23909 · United States
Databases
GENBANK
X01140, X01141, X01142, X01143, X01144, X01145, X01146
External Links
PubMed source DOI: 10.1093/nar/12.22.8381 PMC Full Text View journal details
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