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PMID: 6092064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Analysis of the gene coding for the murine cellular tumour antigen p53.

The EMBO journal ·Vol. 3 ·No. 9 ·1984-09-00 ·Pages 2179-83

Bienz B, Zakut-Houri R, Givol D, Oren M

Abstract

A genomic clone containing the functional gene for the murine p53 cellular tumour antigen was isolated and structurally characterised. The gene contains at least 11 exons and 10 introns, the first intron possessing a length of 6.1 kb. Attempts to determine the exact 5' end of p53 mRNA were inconclusive, probably due to the presence of a remarkable stem and loop structure (delta G degrees approximately equal to -56 kcal/mol) in the 5' region of the gene. Suggestive similarities were found to exist between p53 and the protein product of the myc oncogene.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Restriction Enzymes DNA, Neoplasm/isolation & purification Genes Liver/analysis Mice Mice, Inbred BALB C Neoplasm Proteins/genetics Nucleic Acid Hybridization Phosphoproteins/genetics Tumor Suppressor Protein p53
Chemicals
DNA, Neoplasm Neoplasm Proteins Phosphoproteins Tumor Suppressor Protein p53 DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bienz B
Zakut-Houri R
Givol D
Oren M
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31 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-09-00
Pages
2179-83
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557662
Subset
IM
Databases
GENBANK
X00875, X00876, X00877, X00878, X00879, X00880, X00881, X00882, X00883, X00884, X00885
External Links
PubMed source PMC Full Text View journal details
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