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PMID: 51938 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Variants of N-tropic leukemia virus derived from BALB/c mice.

Journal of virology ·Vol. 16 ·No. 4 ·1975-10-00 ·Pages 991-9

Hopkins N, Jolicoeur P

Abstract

Clonal lines derived from cultures of NIH/3T3 cells infected with N-tropic leukemia virus from BALB/c mice differ in the amount and type of N-tropic virus they produce. Three biologically distinguishable N-tropic viruses were found: the large XC plaque-forming virus of hartley et al. (1969) (LP-N), A SMALL XC plaque-forming virus (sp-n), and a non-plaque-forming virus (NP-N). SP-N and NP-N are less infectious than LP-N. Upon prolonged passage in NIH/3T3 cells NP-N gives rise to highly infectious LP-N.

MeSH Terms

Animals Cell Line Clone Cells Genetic Variation Leukemia Virus, Murine/enzymology,growth & development,pathogenicity Mice Mice, Inbred BALB C Mice, Inbred Strains RNA-Directed DNA Polymerase/metabolism Species Specificity

Chemicals

RNA-Directed DNA Polymerase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hopkins N

Jolicoeur P

References (14)

14 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.16.4.991-999.1975

Published

1975-10-00

Pages

991-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC354761

Subset

External Links

PubMed source DOI: 10.1128/JVI.16.4.991-999.1975 PMC Full Text View journal details

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Variants of N-tropic leukemia virus derived from BALB/c mice.

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