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PMID: 51007 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Evidence for O antigens as the antigenic determinants in "ribosomal" vaccines prepared from Salmonella.

Infection and immunity ·Vol. 12 ·No. 2 ·1975-08-00 ·Pages 364-77

Eisenstein TK

Abstract

The nature of the protective substance in ribosomal ribonucleic acid and protein extracts of Salmonella has been investigated. The results of experiments in which vaccines were prepared from isogenic strains and strains with defects in lipopolysaccharide synthesis show that O antigens contaminate both ribonucleic acid and protein ribosomal extracts, and are responsible for at least part of their strain-specific protective activity. In addition, it was observed that a ribosomal ribonucleic acid preparation from S. adelaide contains a heat-stable immunogen which is not an O antigen or that gives cross-protection across species lines. The contribution of ribosomes to the immunity induced by "ribosomal vaccines" is discussed.

MeSH Terms
Animals Antigens, Bacterial Bacterial Proteins/immunology Bacterial Vaccines Cell Wall/immunology Epitopes Erythrocytes/immunology Female Hemagglutination Tests Hot Temperature Immunity Immunization Immunization, Secondary Mice Mutation RNA, Ribosomal/immunology,isolation & purification Ribosomes/analysis,immunology Salmonella/immunology Salmonella enteritidis/immunology Salmonella typhimurium/immunology Sonication Vaccination
Chemicals
Antigens, Bacterial Bacterial Proteins Bacterial Vaccines Epitopes RNA, Ribosomal
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Eisenstein T K
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30 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.12.2.364-377.1975
Published
1975-08-00
Pages
364-77
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC415293
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.12.2.364-377.1975 PMC Full Text View journal details
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