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PMID: 4564407 Published · ppublish English Journal Article

Ribosomal vaccines. I. Immunogenicity of ribosomal fractions isolated from Salmonella typhimurium and Yersinia pestis.

Infection and immunity ·Vol. 5 ·No. 6 ·1972-06-00 ·Pages 947-52

Johnson W

Abstract

The immunogenicity of ribosomes and ribosomal subfractions isolated from Yersina pestis and Salmonella typhimurium has been studied. Ribosomes and ribosomal protein isolated from S. typhimurium protected mice against lethal challenge. Ribosomal ribonucleic acid isolated by phenol extraction failed to induce any significant level of protection in mice. None of the ribosomes or ribosomal subfractions isolated from Y. pestis were effective in inducing immunity to lethal challenge. These results suggest that the immunogen of the ribosomal vaccine is protein.

MeSH Terms
Animals Antibody Formation Antigens, Bacterial/isolation & purification Bacterial Proteins Bacterial Vaccines Centrifugation, Density Gradient Chromatography Immunization Male Mice Pronase RNA, Bacterial/isolation & purification RNA, Ribosomal/isolation & purification Ribonucleases Ribosomes/immunology Salmonella typhimurium/cytology,immunology Sodium Dodecyl Sulfate Spectrophotometry Sucrose Time Factors Trypsin Ultracentrifugation Yersinia pestis/cytology,immunology
Chemicals
Antigens, Bacterial Bacterial Proteins Bacterial Vaccines RNA, Bacterial RNA, Ribosomal Sodium Dodecyl Sulfate Sucrose Ribonucleases Trypsin Pronase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Johnson W
References (17)
17 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.5.6.947-952.1972
Published
1972-06-00
Pages
947-52
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422469
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.5.6.947-952.1972 PMC Full Text View journal details
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