Cleavage of a viral envelope precursor during the morphogenesis of Sindbis virus.

Journal of virology ·Vol. 13 ·No. 4 ·1974-04-00 ·Pages 809-17

Jones KJ, Waite MR, Bose HR

Abstract

In cells infected with a temperature-sensitive mutant of Sindbis virus, the cleavage of the precursor to one of the viral envelope proteins does not occur at the nonpermissive temperature. This precursor is found associated with the plasma membrane fraction obtained from the infected cell. Since this is the site at which the virus matures, this finding suggests that during Sindbis virus replication the precursor to the smaller proteins associates with the cell membrane and is then cleaved during the maturation of the virus.

MeSH Terms

Animals Cell Membrane/analysis Cells, Cultured Chick Embryo Electrophoresis, Polyacrylamide Gel Hemagglutinins, Viral Leucine Morphogenesis Mutation Peptides/analysis Sindbis Virus Temperature Tritium Viral Proteins/biosynthesis Virus Replication

Chemicals

Hemagglutinins, Viral Peptides Viral Proteins Tritium Leucine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jones K J

Waite M R

Bose H R

References (25)

25 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.13.4.809-817.1974

Published

1974-04-00

Pages

809-17

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC355379

Subset

External Links

PubMed source DOI: 10.1128/JVI.13.4.809-817.1974 PMC Full Text View journal details

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Cleavage of a viral envelope precursor during the morphogenesis of Sindbis virus.

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