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PMID: 450145 Published · ppublish English Journal Article

Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 306 ·No. 2 ·1979-03-00 ·Pages 113-8

Beubler E, Lembeck F

Abstract

暂无摘要

MeSH Terms
Animals Bethanechol Compounds/pharmacology Carbachol/pharmacology Dextrorphan/pharmacology Female In Vitro Techniques Intestinal Secretions/drug effects Intestine, Large/drug effects Intestine, Small/drug effects Levorphanol/pharmacology Loperamide/pharmacology Morphine/pharmacology Naloxone/pharmacology Narcotic Antagonists/pharmacology Prostaglandins E/antagonists & inhibitors Rats Vasoactive Intestinal Peptide/pharmacology
Chemicals
Bethanechol Compounds Narcotic Antagonists Prostaglandins E Dextrorphan Levorphanol Naloxone Vasoactive Intestinal Peptide Loperamide Morphine Carbachol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Beubler E
Lembeck F
References (50)
50 references, click to expand
  1. Loperamide antagonism of castor oil-induced diarrhea in rats: a quantitative study.
    Arch Int Pharmacodyn Ther. 1975 Sep;217(1):29-37 PMID: 1190912
  2. CI-750, A novel antidiarrheal agent.
    J Pharmacol Exp Ther. 1973 Jul;186(1):183-98 PMID: 4198772
  3. Opiate agonist action of antidiarrheal agents in vitro and in vivo--findings in support for selective action.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Jan-Feb;301(3):187-94 PMID: 204876
  4. Enteropooling assay: a test for diarrhea produced by prostaglandins.
    Prostaglandins. 1976 May;11(5):809-28 PMID: 935512
  5. Stimulation of adenylate cyclase in homogenates of isolated intestinal epithelial cells from hamsters. Effects of gastrointestinal hormones, prostaglandins, and deoxycholic and ricinoleic acids.
    Gastroenterology. 1978 Jan;74(1):11-5 PMID: 562812
  6. Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum.
    Gastroenterology. 1971 Jan;60(1):22-32 PMID: 5544090
  7. Inhibition by morphine of the release of acetylcholine from the intestine of the guinea-pig.
    Br J Pharmacol Chemother. 1957 Mar;12(1):115-8 PMID: 13413162
  8. Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.
    Arzneimittelforschung. 1974 Oct;24(10):1633-6 PMID: 4479775
  9. Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.
    Nature. 1974 Mar 1;248(5443):24-7 PMID: 4361995
  10. Is the effect of diphenolic laxatives mediated via release of prostaglandin E?
    Experientia. 1978 Mar 15;34(3):386-7 PMID: 631275
  11. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance.
    Lancet. 1976 May 8;1(7967):991-3 PMID: 57443
  12. The effect of loperamide on prostaglandin induced diarrhoea in rat and man.
    Prostaglandins. 1977 Feb;13(2):321-31 PMID: 847235
  13. The action of morphine, pethidine, and amidone upon the intestinal motility of conscious dogs.
    Br J Pharmacol Chemother. 1950 Dec;5(4):584-603 PMID: 14801464
  14. Adenylate cyclase in intestinal crypt and villus cells: stimulation by cholera enterotoxin and prostaglandin E1.
    Gastroenterology. 1975 Jan;68(1):94-104 PMID: 1116669
  15. Prostaglandins in amine-peptide-secreting tumours.
    Lancet. 1968 Nov 16;2(7577):1053-4 PMID: 4176865
  16. Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues.
    Arzneimittelforschung. 1974 Oct;24(10):1641-5 PMID: 4479777
  17. Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.
    J Clin Invest. 1971 Jun;50(6):1218-30 PMID: 4325309
  18. Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.
    Prostaglandins. 1974 Sep 10;7(5):361-76 PMID: 4371639
  19. Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon.
    Eur J Biochem. 1972 Jul 13;28(2):199-204 PMID: 5069712
  20. Inhibition by morphine of prostaglandin-stimulated fluid secretion in rat jejunum.
    Br J Pharmacol. 1978 May;63(1):57-63 PMID: 647163
  21. Effects of PGE2 and colchicine on the intestinal fluid volume.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Jan-Feb;301(3):195-9 PMID: 273148
  22. Identification of two related pentapeptides from the brain with potent opiate agonist activity.
    Nature. 1975 Dec 18;258(5536):577-80 PMID: 1207728
  23. Prostaglandin production by rabbit isolated jejunum and its relationship to the inherent tone of the preparation.
    Br J Pharmacol. 1976 Apr;56(4):469-77 PMID: 1260227
  24. The function of prostaglandins in transmucosal water movement and blood flow in the rat jejunum.
    Naunyn Schmiedebergs Arch Pharmacol. 1977 Aug;299(1):89-94 PMID: 904696
  25. Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.
    Adv Prostaglandin Thromboxane Res. 1976;2:507-20 PMID: 983858
  26. PGE-mediated laxative effect of diphenolic laxatives.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):241-6 PMID: 740051
  27. Prostaglandin secretion by medullary carcinoma of the thyroid. A possible cause of the associated idarrhoea.
    Lancet. 1968 Jan 6;1(7532):22-3 PMID: 4169067
  28. Enkephalin-like immunoreactivity in the human gastrointestinal tract.
    Lancet. 1977 May 7;1(8019):972-4 PMID: 67467
  29. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.
    Br J Pharmacol Chemother. 1957 Mar;12(1):119-27 PMID: 13413163
  30. Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa.
    J Clin Invest. 1974 Sep;54(3):536-44 PMID: 4369434
  31. Morphine antagonizes the action of prostaglandin in neuroblastoma cells but not of prostaglandin and noradrenaline in glioma and glioma times fibroblast hybrid cells.
    FEBS Lett. 1974 Dec 15;49(2):260-3 PMID: 4374398
  32. Single neuron studies of opiate action in the guinea pig myenteric plexus.
    Life Sci. 1975 Jul 1;17(1):57-62 PMID: 1143011
  33. Effects of E prostaglandins, diphenoxylate and morphine on intestinal motility in vivo.
    Eur J Pharmacol. 1975 Nov;34(1):105-13 PMID: 1234756
  34. Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.
    J Clin Invest. 1974 Mar;53(3):941-9 PMID: 4359941
  35. Inhibition by met-enkephalin of peristaltic activity in the guinea pig ileum, and its reversal by naloxone.
    Eur J Pharmacol. 1977 Feb 7;41(3):341-2 PMID: 837977
  36. Interactions of opiates and prostaglandins E with regard to cyclic AMP in striatal tissue of rats in vitro.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):103-6 PMID: 206843
  37. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate.
    Lancet. 1975 Nov 15;2(7942):942-3 PMID: 53429
  38. Active chloride transport during intestinal secretion.
    Am J Physiol. 1961 Feb;200:309-12 PMID: 13776834
  39. Centrally mediated intestinal stimulation by morphine.
    J Pharmacol Exp Ther. 1977 Jul;202(1):174-81 PMID: 874814
  40. Effect of prostaglandin E 1 on glucose, water, and electrolyte absorption in the human jejunum.
    Gastroenterology. 1973 Jun;64(6):1111-8 PMID: 4706129
  41. Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate.
    Arzneimittelforschung. 1974 Oct;24(10):1636-41 PMID: 4479776
  42. Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection.
    Gut. 1977 Jul;18(7):575-9 PMID: 326642
  43. Morphine antagonises action of prostaglandin in neuroblastoma and neuroblastoma times glioma hybrid cells.
    Nature. 1975 Jan 10;253(5487):120-2 PMID: 163008
  44. PGE-release, blood flow and transmucosal water movement after mechanical stimulation of the rat jejunal mucosa.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;305(1):91-5 PMID: 723974
  45. Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study.
    Acta Med Scand. 1977;202(6):449-54 PMID: 339672
  46. Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus.
    J Pharmacol Exp Ther. 1977 Dec;203(3):527-38 PMID: 200732
  47. [Water and electrolyte movement in the small intestine and colon under the influence of laxatives, a contribution to the clearing of their mechanism of action].
    Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;254(1):18-32 PMID: 4226512
  48. The pharmacology of SC-27166: a novel antidiarrheal agent.
    J Pharmacol Exp Ther. 1977 Dec;203(3):512-26 PMID: 411912
  49. Endogenous opiates and the digestive system.
    Scand J Gastroenterol. 1978;13(3):257-61 PMID: 384499
  50. Vasoactive intestinal polypeptide: abundant immunoreactivity in neural cell lines and normal nervous tissue.
    Science. 1976 May 28;192(4242):907-8 PMID: 1273576
Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00498980
Published
1979-03-00
Pages
113-8
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00498980 View journal details
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