Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues.

Amides/pharmacology Animals Antidiarrheals/pharmacology Cats Cecum/drug effects Chickens Chlorobenzenes/pharmacology Duodenum/drug effects Electric Stimulation Gastrointestinal Agents/pharmacology Gastrointestinal Motility/drug effects Guinea Pigs Heart Rate/drug effects Histamine/pharmacology Ileum/drug effects In Vitro Techniques Isoproterenol/pharmacology Muscle Contraction/drug effects Muscle Tonus/drug effects Muscle, Smooth/drug effects Nicotine/antagonists & inhibitors Papillary Muscles/drug effects Peristalsis/drug effects Piperidines/pharmacology Rabbits Rats Spleen/drug effects Stomach/drug effects

Amides Antidiarrheals Chlorobenzenes Gastrointestinal Agents Piperidines Nicotine Histamine Isoproterenol