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PMID: 53429 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Treatment of radiation-induced gastrointestinal distress with acetylsalicylate.

Lancet (London, England) ·Vol. 2 ·No. 7942 ·1975-11-15 ·Pages 942-3

Mennie AT, Dalley VM, Dinneen LC, Collier HO

Abstract

Highly buffered acetylsalicylate was used to treat diarrhoea and other gastrointestinal side-effects of radiotherapy in 28 women who were receiving treatment for uterine cancer. In a double-blind, balanced, and randomised trial, acetylsalicylate significantly reduced the number of bowel motions and relieved abdominal pain and flatulence.

MeSH Terms

Antacids/administration & dosage,therapeutic use Aspirin/administration & dosage,therapeutic use Buffers Clinical Trials as Topic Diarrhea/drug therapy,etiology Drug Combinations Drug Evaluation Female Humans Nausea/drug therapy,etiology Radiation Injuries/drug therapy Radiotherapy/adverse effects Uterine Cervical Neoplasms/radiotherapy

Chemicals

Antacids Buffers Drug Combinations Aspirin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mennie A T

Dalley V M

Dinneen L C

Collier H O

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(75)90358-x

Published

1975-11-15

Pages

942-3

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(75)90358-x View journal details

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Treatment of radiation-induced gastrointestinal distress with acetylsalicylate.

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