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PMID: 4405612 Published · ppublish English Journal Article

Characterization of the coronary vascular -adrenoceptor in the pig.

British journal of pharmacology ·Vol. 46 ·No. 2 ·1972-10-00 ·Pages 348-50

Drew GM, Levy GP

Abstract

The beta-adrenoceptor in pig coronary vascular smooth muscle has been characterized by the use of a selective agonist, salbutamol and a selective antagonist, practolol. In coronary artery strips contracted with KCI, salbutamol had only marginal relaxant activity and was a partial agonist compared with isoprenaline. Practolol had relatively high antagonist potency against isoprenaline (pA(2) 6.59). It is concluded that the pig coronary vascular,beta-adrenoceptor is of the beta(1)-type.

MeSH Terms
Acetanilides/pharmacology Adrenergic beta-Antagonists/administration & dosage,pharmacology Amino Alcohols/pharmacology Animals Bronchodilator Agents/pharmacology Coronary Vessels/drug effects In Vitro Techniques Isoproterenol/administration & dosage,antagonists & inhibitors Muscle, Smooth/drug effects Potassium Chloride/pharmacology Receptors, Adrenergic Swine
Chemicals
Acetanilides Adrenergic beta-Antagonists Amino Alcohols Bronchodilator Agents Receptors, Adrenergic Potassium Chloride Isoproterenol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Drew G M
Levy G P
References (20)
20 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1972.tb06880.x
Published
1972-10-00
Pages
348-50
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1666354
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1972.tb06880.x PMC Full Text View journal details
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