Some quantitative uses of drug antagonists.

British journal of pharmacology and chemotherapy ·Vol. 14 ·No. 1 ·1959-03-00 ·Pages 48-58

ARUNLAKSHANA O, SCHILD HO

Abstract

Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.

Keywords

DRUGS

MeSH Terms

Acetylcholine Atropine Histamine Pharmaceutical Preparations

Chemicals

Pharmaceutical Preparations Atropine Histamine Acetylcholine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

ARUNLAKSHANA O

SCHILD H O

References (12)

12 references, click to expand

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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1959.tb00928.x

Published

1959-03-00

Pages

48-58

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1481829

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1959.tb00928.x PMC Full Text

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