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PMID: 4372412 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Type-C RNA virus gene expression in human tissue.

Journal of virology ·Vol. 14 ·No. 6 ·1974-12-00 ·Pages 1584-96

Strand M, August JT

Abstract

Partially purified fractions of human tissues have been analyzed by competition radioimmunoassay for the presence of two of the principle structural components of type-C RNA viruses, the major core protein (p27 to p30) and the major envelope glycopeptides (gp69/71). Screening of tissues was carried out by use of a heterologous assay system of (125)I-labeled Rauscher murine virus p30 antigen and anti-RD 114 virus serum which was found to detect a class of interspecies determinants common to murine, feline, and primate viruses. A competitor with the same apparent affinity for antibody binding as that of purified viral core proteins was found in relatively high concentration in tissues from patients with systemic lupus erythematosus, in some neoplastic tissues, and also in normal human tissues. This competitor from a lupus spleen chromatographed on phosphocellulose and showed size fractionation during gel filtration similar to known p27 to p30 viral proteins. An immunologically reactive protein was also demonstrated by immunodiffusion and by immunoprecipitation of (125)I-labeled human protein with anti-RD 114 p28 serum. Analysis of these human competitor proteins with homologous assay systems of viral core proteins and corresponding antisera showed that all, including the normal tissue extracts, appear similar to core proteins of known viruses, especially the RD 114 and woolly monkey species. A hypothesis suggested by these data is that many, if not all, humans harbor at least part of the genome of one or more type-C viruses, the properties of which are similar to those of viruses from other mammalian species, particularly primates.

MeSH Terms
Adenocarcinoma/genetics Carcinoma, Hepatocellular/genetics Carcinoma, Transitional Cell/genetics Fibrosarcoma/genetics Glycopeptides/analysis Humans Immunodiffusion In Vitro Techniques Kidney/analysis Kidney Neoplasms/genetics Liver/analysis Liver Neoplasms Lupus Erythematosus, Systemic/genetics Lymphoma, Large B-Cell, Diffuse/genetics Lymphoma, Non-Hodgkin/genetics Neoplasms/genetics Phenotype Placenta/analysis Purpura, Thrombocytopenic/genetics Radioimmunoassay Retroviridae Rhabdomyosarcoma/genetics Spleen/analysis Trophoblasts/analysis Viral Proteins/analysis
Chemicals
Glycopeptides Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Strand M
August J T
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.14.6.1584-1596.1974
Published
1974-12-00
Pages
1584-96
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC355688
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.14.6.1584-1596.1974 PMC Full Text View journal details
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