Baboon virus isolate M-7 with properties similar to feline virus RD-114.

Journal of virology ·Vol. 14 ·No. 1 ·1974-07-00 ·Pages 133-8

Hellman A, Peebles PT, Strickland JE, Fowler AK, Kalter SS, Oroszlan KS, Gilden RV

Abstract

A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 virus has helper activity as demonstrated by rescue of murine sarcoma virus (MSV) from sarcoma-positive leukemia-negative human amnion cells. The host range of the rescued M-7 pseudotype of MSV, MSV (M-7), is similar to that of RD-114 virus. MSV (M-7) is also able to transform baboon cells and causes no detectable transformation of feline cells without addition of helper feline leukemia virus. Interference properties of M-7 and RD-114 virus are identical. Virus-specific neutralizing antisera, although partially cross-reacting, can distinguish MSV (M-7) from MSV (RD-114). These similarities and differences between RD-114 and M-7 viruses are best explained as type-specific differences between two viruses within the same strain.

MeSH Terms

Amnion Animals Antigens, Viral/analysis Cell Line Fibroblasts Helper Viruses Humans Immunodiffusion In Vitro Techniques Kidney Mice Mice, Inbred Strains/embryology Neutralization Tests Papio Placenta/microbiology RNA-Directed DNA Polymerase/analysis Retroviridae/isolation & purification Viral Interference

Chemicals

Antigens, Viral RNA-Directed DNA Polymerase

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Hellman A

Peebles P T

Strickland J E

Fowler A K

Kalter S S

Oroszlan K S

Gilden R V

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.14.1.133-138.1974

Published

1974-07-00

Pages

133-8

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC355486

Subset

External Links

PubMed source DOI: 10.1128/JVI.14.1.133-138.1974 PMC Full Text View journal details

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Baboon virus isolate M-7 with properties similar to feline virus RD-114.

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