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PMID: 4352660 Published · ppublish English Journal Article

Common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 6 ·1973-06-00 ·Pages 1878-82

Yoshiki T, Mellors RC, Hardy WD

Abstract

A new common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses was demonstrated by the use of rabbit antiserum against feline leukemia virus and the indirect membrane immunofluorescence test. Common cell-surface antigen was found in all leukemias of all strains of mice tested, in normal lymphoid tissues of Gross-positive (high incidence of leukemia) mouse strains AKR, AKR.H-2(b), C58, and NZB, in cultured rat fibroblasts infected with Rauscher virus, in cultured feline fibroblasts infected with feline leukemia virus, and in spontaneous feline lymphosarcoma. The antigen was not demonstrable in normal adult and fetal tissues of Gross-negative mouse strains or in tissues and cultured fibroblasts derived from normal rats and normal cats. The immunoferritin study of murine leukemia cells revealed that the antigen was located on the cell surface in discrete areas; budding and C-type RNA viral envelope was not labeled as antigen site. The distribution of common cell-surface antigen on murine and feline leukemias, as well as on normal lymphoid tissues of Gross-positive mouse strains, indicates the presence of an antigen distinct from any cell-surface antigen heretofore shown to be associated with, or specified by, mammalian C-type RNA viruses.

MeSH Terms
Animals Antigen-Antibody Reactions Antigens, Neoplasm/analysis Antigens, Viral/analysis Cell Membrane/immunology Cells, Cultured Ferritins Fibroblasts Fluorescent Antibody Technique Leukemia Virus, Feline/immunology Leukemia Virus, Murine/immunology Leukemia, Experimental/immunology Lymphoma, Non-Hodgkin/immunology Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred NZB Mice, Inbred Strains Microscopy, Electron Rabbits/immunology Rauscher Virus/immunology Retroviridae/immunology
Chemicals
Antigens, Neoplasm Antigens, Viral Ferritins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yoshiki T
Mellors R C
Hardy W D
References (28)
28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.6.1878
Published
1973-06-00
Pages
1878-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433617
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.6.1878 PMC Full Text View journal details
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