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PMID: 427004 Published · ppublish English Journal Article

Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency.

British journal of clinical pharmacology ·Vol. 7 ·No. 3 ·1979-03-00 ·Pages 273-82

Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, Verberckmoes R, de Schepper PJ

Abstract

暂无摘要

MeSH Terms
Adult Analgesics/metabolism Biotransformation Biphenyl Compounds/metabolism Creatinine/blood Glucuronates/urine Half-Life Humans Kidney Failure, Chronic/metabolism Kinetics Male Renal Dialysis
Chemicals
Analgesics Biphenyl Compounds Glucuronates Creatinine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Verbeeck R
Tjandramaga T B
Mullie A
Verbesselt R
Verberckmoes R
de Schepper P J
References (12)
12 references, click to expand
  1. Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis.
    J Clin Invest. 1959 Sep;38:1498-508 PMID: 14412753
  2. Drug kinetics and artificial kidneys.
    Clin Pharmacokinet. 1977 Nov-Dec;2(6):403-26 PMID: 22417
  3. The biotransformation of drugs in renal failure.
    Am J Med. 1977 Apr;62(4):482-5 PMID: 851117
  4. The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol.
    Br J Clin Pharmacol. 1976 Apr;3(2):259-65 PMID: 973960
  5. Drug administration in renal failure.
    Am J Med. 1977 Apr;62(4):555-63 PMID: 851131
  6. Diflunisal: efficacy in postoperative pain.
    Br J Clin Pharmacol. 1977 Feb;4 Suppl 1:39S-43S PMID: 328033
  7. A guide to drug therapy in renal failure.
    JAMA. 1974 Dec 16;230(11):1544-53 PMID: 4154380
  8. Individualization of drug dosage in patients with renal disease.
    Med Clin North Am. 1974 Sep;58(5):977-85 PMID: 4425338
  9. Physiological disposition and metabolism of 5-(2',4'-difluorophenyl)salicyclic acid, a new salicylate.
    Drug Metab Dispos. 1975 Nov-Dec;3(6):453-66 PMID: 1220
  10. Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man.
    Clin Pharmacol Ther. 1972 Mar-Apr;13(2):258-68 PMID: 4552824
  11. Pharmacokinetics of acetaminophen elimination by anephric patients.
    J Pharmacol Exp Ther. 1976 Mar;196(3):570-8 PMID: 1263112
  12. Drug biotransformation interactions in man. I. Mutual inhibition in glucuronide formation of salicylic acid and salicylamide in man.
    J Pharm Sci. 1968 Aug;57(8):1330-5 PMID: 5677334
Article Info
Journal
British journal of clinical pharmacology
Abbr.
Br J Clin Pharmacol
ISSN
0306-5251
DOI
10.1111/j.1365-2125.1979.tb00932.x
Published
1979-03-00
Pages
273-82
Language
English
Region
England
NLM ID
7503323
PMCID
PMC1429486
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2125.1979.tb00932.x PMC Full Text View journal details
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