The biotransformation of drugs in renal failure.

Studies of the rates of elimination of drugs normally biotransformed in man have been carried out in uremic patients. Drug oxidations are normal or accelerated. Reduction is slowed. Glucuronide and glycine conjugations are normal whereas acetylation may be normal or slowed. Many hydrolyses are slowed. Thus, the usual dosages of metabolized drugs may have to be altered to properly individualize therapy for patients with renal failure.