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PMID: 4217587 Published · ppublish English Journal Article

Penicillin: reversible inhibition of forespore septum development in Bacillus megaterium cells.

Antimicrobial agents and chemotherapy ·Vol. 6 ·No. 6 ·1974-12-00 ·Pages 815-20

Lawrence PJ

Abstract

Benzylpenicillin inhibits the development of the forespore septum in sporulating Bacillus megaterium cells. The inhibitory effect is a function of the duration of exposure to the antibiotic and is completely reversible by penicillinase. Under the incubation conditions employed, less than 20% of the covalently bound antibiotic is released from the cells. The penicillin which remains bound to the cells after treatment with penicillinase may be necessary but is not sufficient for the effect; unbound antibiotic in the sporulation medium is also required.

MeSH Terms
Bacillus megaterium/drug effects,metabolism,ultrastructure Carbon Radioisotopes Penicillin G/metabolism,pharmacology Penicillinase/pharmacology Spores, Bacterial/drug effects,growth & development Time Factors
Chemicals
Carbon Radioisotopes Penicillinase Penicillin G
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lawrence P J
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22 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.6.6.815
Published
1974-12-00
Pages
815-20
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444742
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.6.6.815 PMC Full Text View journal details
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