Correlation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus.

Journal of bacteriology ·Vol. 99 ·No. 2 ·1969-08-00 ·Pages 459-62

Edwards JR, Park JT

Abstract

The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.

MeSH Terms

Ampicillin/pharmacology Binding Sites Carbon Isotopes Cephaloridine/pharmacology Cephalosporins/pharmacology Cephalothin/pharmacology Cloxacillin/pharmacology Methicillin/pharmacology Oxacillin/pharmacology Penicillin G/metabolism,pharmacology Penicillins/pharmacology Staphylococcus/drug effects,growth & development,metabolism

Chemicals

Carbon Isotopes Cephalosporins Penicillins Ampicillin Cephaloridine Cloxacillin Penicillin G Methicillin Cephalothin Oxacillin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Edwards J R

Park J T

References (15)

15 references, click to expand

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PENICILLIN UPTAKE BY BACTERIAL CELLS.
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Glycopeptide transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions.
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J Bacteriol. 1954 Mar;67(3):321-8 PMID: 13142998
The site of action of penicillin: some properties of the penicillin-binding component of Staphylococcus aureus.
J Gen Microbiol. 1955 Feb;12(1):100-6 PMID: 14354138
The association of the penicillin-binding component of Staphylococcus aureus with a lipid fraction.
J Gen Microbiol. 1954 Apr;10(2):236-45 PMID: 13152334
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J Exp Med. 1954 Mar;99(3):207-26 PMID: 13130795
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The nature of the binding of penicillin by bacterial cells.
J Bacteriol. 1956 Jan;71(1):84-90 PMID: 13286234
Site of action of radiopenicillin.
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A note on the use of radioactive penicillin.
J Gen Microbiol. 1954 Apr;10(2):246-9 PMID: 13152335
BIOSYNTHESIS OF CELL WALL MUCOPEPTIDE BY A PARTICULATE FRACTION FROM STAPHYLOCOCCUS AUREUS.
Proc Natl Acad Sci U S A. 1964 Jan;51:9-16 PMID: 14106674
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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.99.2.459-462.1969

Published

1969-08-00

Pages

459-62

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC250038

Subset

External Links

PubMed source DOI: 10.1128/jb.99.2.459-462.1969 PMC Full Text View journal details

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Correlation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus.

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