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PMID: 4134726 Published · ppublish English Journal Article

Adrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 8 ·1973-08-00 ·Pages 2391-5

Paran M, Gallo RC, Richardson LS, Wu AM

Abstract

Induction of RNA "tumor" viruses by 5-iodo-2'-deoxyuridine in mouse fibroblasts is stimulated 5- to 25-fold by glucogenic adrenal corticosteroids. Enhancement of virus production by the hormones is inhibited by low concentration of cordycepin, an inhibitor of poly(A) synthesis.

MeSH Terms
Animals Clone Cells Deoxyadenosines/pharmacology Dexamethasone/pharmacology Drug Synergism Fibroblasts Gammaretrovirus/drug effects Glucocorticoids/antagonists & inhibitors,pharmacology Gonadal Steroid Hormones/pharmacology Idoxuridine/pharmacology Insulin/pharmacology Kinetics Mice Prednisolone/pharmacology RNA-Directed DNA Polymerase/metabolism Retroviridae/drug effects,enzymology Thymidine/biosynthesis Viral Plaque Assay Virus Replication/drug effects
Chemicals
Deoxyadenosines Glucocorticoids Gonadal Steroid Hormones Insulin Dexamethasone Prednisolone RNA-Directed DNA Polymerase Idoxuridine Thymidine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Paran M
Gallo R C
Richardson L S
Wu A M
References (29)
29 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.8.2391
Published
1973-08-00
Pages
2391-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433742
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.8.2391 PMC Full Text View journal details
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