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PMID: 4118874 Published · ppublish English Journal Article

Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 12 ·1972-12-00 ·Pages 3820-4

Wu AM, Ting RC, Paran M, Gallo RC

Abstract

Cordycepin (3'-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2'-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA.

MeSH Terms
Adenosine/pharmacology Cell Line Cephalothin/pharmacology Cyclic AMP/pharmacology Dactinomycin/pharmacology Deoxyadenosines/pharmacology Deoxyuridine/antagonists & inhibitors,pharmacology Gammaretrovirus/drug effects,enzymology,growth & development RNA-Directed DNA Polymerase/metabolism
Chemicals
Deoxyadenosines Dactinomycin Cyclic AMP RNA-Directed DNA Polymerase Adenosine Cephalothin Deoxyuridine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wu A M
Ting R C
Paran M
Gallo R C
References (16)
16 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.12.3820
Published
1972-12-00
Pages
3820-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC389881
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.12.3820 PMC Full Text View journal details
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