Abstract
The relationship between 7S anti-IgG and antibodies to streptococcal cell wall peptidoglycan was examined for four streptococcal Group C antisera. Homogeneous 7S anti-IgG components in these sera were isolated by means of an IgG immunoadsorbent column. For two of the four antisera, the anti-peptidoglycan activity of the 7S anti-IgG had specificity for the pentapeptide, L-Ala-D-Glu-gamma-L-Lys-D-Ala-D-Ala, the antigenic determinant of peptidoglycan, as well as for the Fc of IgG. Detailed studies on the 7S anti-IgG from one of the antisera revealed that the pentapeptide inhibited the coprecipitation reaction of 7S anti-IgG R3387 with antigen-antibody complexes and the precipitin reaction between 7S anti-IgG R3387 and its anti-idiotype serum.
MeSH Terms
Animals
Antibodies, Anti-Idiotypic/analysis
Antibody Specificity
Antigen-Antibody Complex
Binding Sites, Antibody
Cell Wall/immunology
Epitopes
Immunoglobulin Fc Fragments
Immunoglobulin G
Peptides/pharmacology
Peptidoglycan
Precipitin Tests
Rabbits/immunology
Streptococcus/immunology
Chemicals
Antibodies, Anti-Idiotypic
Antigen-Antibody Complex
Epitopes
Immunoglobulin Fc Fragments
Immunoglobulin G
Peptides
Peptidoglycan
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bokisch V A
Chiao J W
Bernstein D
Krause R M
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