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PMID: 41193 Published · ppublish English Journal Article

Adenosine effects upon transmitter release parameters in the Mg2+-paralyzed neuro-muscular junction of frog.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 308 ·No. 3 ·1979-09-00 ·Pages 273-9

Brănişteanu DD, Haulică ID, Proca B, Nhue BG

Abstract

The influence of adenosine upon the process of transmitter release was investigated in Mg2+-paralyzed frog neuromuscular junction by using conventional microelectrophysiological techniques and binomial statistical analysis. The statistical parameters used were: m (mean number of quanta released per impulse), p (the probability of quantal release) and n (store of quanta available for release). Adenosine decreased the mean quantal content (m) by reducing n. This effect appeared to be dependent upon the free intracellular Ca2+. The nucleoside competed with the transmitter releasing effects of ouabain and increased the amount of effective Ca2+ necessary for quantal release. It did not change the slope of release parameters modification during low-frequency facilitation. The data are discussed in terms of a physical model of release.

MeSH Terms
Adenosine/pharmacology Animals Anura Calcium/pharmacology Magnesium/pharmacology Neuromuscular Junction/drug effects Neurotransmitter Agents/metabolism Ouabain/pharmacology Ranidae Time Factors
Chemicals
Neurotransmitter Agents Ouabain Magnesium Adenosine Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brănişteanu D D
Haulică I D
Proca B
Nhue B G
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35 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00501393
Published
1979-09-00
Pages
273-9
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00501393 View journal details
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