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PMID: 4365809 Published · ppublish English Journal Article

A statistical analysis of the release of acetylcholine at newly formed synapses in striated muscle.

The Journal of physiology ·Vol. 238 ·No. 1 ·1974-04-00 ·Pages 93-107

Bennett MR, Florin T

Abstract

1. A statistical analysis has been made of the changes in the binomial parameters n and p during transmitter release from motor-nerve terminals when synapses are forming in either regenerating or reinnervated mammalian muscle.2. The amplitude-frequency distribution of e.p.p.s evoked by a single impulse was well predicted by binomial statistics at all junctions analysed allowing values of n and p to be determined. At most of these junctions, p > 0.5 and Poisson statistics did not predict the observed distributions at all.3. During the changes in quantal content which occur during short trains of impulses or during continual stimulation over minutes, no significant change in p was detected. Changes in quantal content of the e.p.p. were therefore determined by n.

MeSH Terms
Acetylcholine/metabolism Animals Electric Stimulation Electrophysiology Evoked Potentials In Vitro Techniques Models, Neurological Muscles/innervation,physiology Neuromuscular Junction/physiology Rats Regeneration Statistics as Topic Synapses/metabolism Synaptic Transmission
Chemicals
Acetylcholine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bennett M R
Florin T
References (24)
24 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1974.sp010512
Published
1974-04-00
Pages
93-107
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1330864
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1974.sp010512 PMC Full Text View journal details
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