Home LiteratureArticle Details
PMID: 1080551 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Quantal release parameters during fade of endplate potentials.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 288 ·No. 2-3 ·1975-00-00 ·Pages 323-7

Branisteanu DD, Miyamoto MD, Volle RL

Abstract

An analog of hemicholinium-3 caused the fade of endplate potentials during repetitive stimulation at low rates. The quantal parameters of release were estimated during steady-state conditions before and in the presence of the drug. The fade of EPP's was associated with a decrease in quantal content (m). The decrease in m was, in turn, associated with a decrease in the binomial parameter n and an increase in the binomial parameter p. The changes in n and p are discussed in relation to available stores of transmitter and the probability of transmitter release.

MeSH Terms
Action Potentials/drug effects Animals Anura Electric Stimulation In Vitro Techniques Motor Endplate/physiology Muscles/drug effects Neuromuscular Junction/physiology Quaternary Ammonium Compounds/pharmacology Rana pipiens Sciatic Nerve/physiology
Chemicals
Quaternary Ammonium Compounds
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Branisteanu D D
Miyamoto M D
Volle R L
References (11)
11 references, click to expand
  1. Estimates of statistical release parameters from crayfish and frog neuromuscular junctions.
    J Physiol. 1975 Jan;244(1):207-21 PMID: 164536
  2. Antagonism of ganglionic stimulants by alpha, alpha'-bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p'-diacetylbiphenyl bromide (DMAE).
    J Pharmacol Exp Ther. 1968 Nov;164(1):176-84 PMID: 5722100
  3. Changes in the statistics of transmitter release during facilitation.
    J Physiol. 1973 Mar;229(3):787-810 PMID: 4348351
  4. Binomial analysis of quantal transmitter release at glycerol treated frog neuromuscular junctions.
    J Physiol. 1975 Aug;250(1):121-42 PMID: 240928
  5. Frequency dependent decrease of quantal content in a drug-treated neuromuscular junction.
    Naunyn Schmiedebergs Arch Pharmacol. 1973;278(3):271-84 PMID: 4354638
  6. Effect of quaternary ammonium compounds on radiocalcium movements in nerve.
    Am J Physiol. 1972 May;222(5):1191-8 PMID: 4336714
  7. The effects of calcium and magnesium on statistical release parameters at the crayfish neuromuscular junction.
    J Physiol. 1972 Nov;226(3):761-8 PMID: 4404687
  8. The binomial nature of transmitter release at the crayfish neuromuscular junction.
    J Physiol. 1971 Nov;218(3):757-67 PMID: 4332380
  9. A further study of the statistical composition on the end-plate potential.
    J Physiol. 1955 Oct 28;130(1):114-22 PMID: 13278890
  10. Quantal components of the end-plate potential.
    J Physiol. 1954 Jun 28;124(3):560-73 PMID: 13175199
  11. A statistical analysis of the release of acetylcholine at newly formed synapses in striated muscle.
    J Physiol. 1974 Apr;238(1):93-107 PMID: 4365809
Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00500538
Published
1975-00-00
Pages
323-7
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00500538 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2