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PMID: 4074339 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Glycolytic origin of alanine formed in rat diaphragm muscle in vitro.

The Biochemical journal ·Vol. 231 ·No. 3 ·1985-11-01 ·Pages 801-4

Caldecourt MA, Cox DJ, Sugden MC, Palmer TN

Abstract

In quarter-diaphragms from 40 h-starved rats the rate of glycogen mobilization is sufficient to account for the rate of lactate+pyruvate+alanine production. It is concluded, therefore, that alanine derives its carbon skeleton predominantly via glycolysis and not via synthesis de novo from tricarboxylic acid-cycle intermediates and related amino acids.

MeSH Terms

Alanine/metabolism Amino Acids, Branched-Chain/metabolism Animals Diaphragm/metabolism Glycogen/metabolism Glycolysis In Vitro Techniques Male Muscles/metabolism Rats Rats, Inbred Strains Starvation/metabolism

Chemicals

Amino Acids, Branched-Chain Glycogen Alanine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Caldecourt M A

Cox D J

Sugden M C

Palmer T N

References (16)

16 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2310801

Published

1985-11-01

Pages

801-4

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1152823

Subset

External Links

PubMed source DOI: 10.1042/bj2310801 PMC Full Text View journal details

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Glycolytic origin of alanine formed in rat diaphragm muscle in vitro.

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