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PMID: 3980088 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Large plasmids associated with virulence in Shigella species have a common function necessary for epithelial cell penetration.

Infection and immunity ·Vol. 48 ·No. 1 ·1985-04-00 ·Pages 260-2

Watanabe H, Nakamura A

Abstract

Large plasmids (120 to 140 megadaltons) associated with virulence of Shigella sonnei, S. flexneri 2a and S. dysenteriae 1 were transferred from each strain into Escherichia coli K-12 and avirulent S. flexneri 1b strains by ampicillin transposon (Tn1)-mediated conduction. Strains with the virulence plasmid could penetrate tissue culture cells irrespective of the original host of the plasmid.

MeSH Terms

Animals Cells, Cultured Epithelium/microbiology Macaca mulatta Plasmids Shigella/genetics,pathogenicity Virulence

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Watanabe H

Nakamura A

References (16)

16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.48.1.260-262.1985

Published

1985-04-00

Pages

260-2

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC261946

Subset

External Links

PubMed source DOI: 10.1128/iai.48.1.260-262.1985 PMC Full Text View journal details

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Large plasmids associated with virulence in Shigella species have a common function necessary for epithelial cell penetration.

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