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PMID: 3806800 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Instability of large direct repeats in retrovirus vectors.

Journal of virology ·Vol. 61 ·No. 3 ·1987-03-00 ·Pages 925-7

Rhode BW, Emerman M, Temin HM

Abstract

Retrovirus vectors were constructed with large (0.85- to 1.3-kilobase-pair) direct repeats in their genomes. Deletions involving the direct repeats occurred at a high frequency. Deletions occurred both when the direct repeats were in tandem and when they were separated by additional sequences. These deletions occurred during virus replication.

MeSH Terms
Base Sequence Chromosome Deletion DNA, Viral/genetics Genetic Vectors Repetitive Sequences, Nucleic Acid Retroviridae/genetics Spleen Focus-Forming Viruses/genetics Virus Replication
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rhode B W
Emerman M
Temin H M
References (20)
20 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.3.925-927.1987
Published
1987-03-00
Pages
925-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254040
Subset
IM
Grants
NCI NIH HHS · CA-07215 · United States
NCI NIH HHS · CA-09135-10 · United States
NCI NIH HHS · CA-2243 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.3.925-927.1987 PMC Full Text View journal details
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