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PMID: 3785181 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.

Molecular and cellular biology ·Vol. 6 ·No. 5 ·1986-05-00 ·Pages 1834-7

Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams JM

Abstract

Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral integration site in retrovirally induced rat T lymphomas, while the pvt-1 locus on murine chromosome 15 frequently translocates to the kappa locus in plasmacytomas bearing 6;15 translocations. By comparing cloned sequences, we show that pvt-1 is the murine homolog of Mis-1.

MeSH Terms

Animals Cell Line Clone Cells Cloning, Molecular Genes, Viral Mice Mice, Inbred C57BL Nucleic Acid Hybridization Oncogenes Plasmacytoma/genetics Rats Thymoma/genetics,microbiology Thymus Neoplasms/genetics,microbiology Transcription, Genetic Translocation, Genetic

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Villeneuve L

Rassart E

Jolicoeur P

Graham M

Adams J M

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26 references, click to expand

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Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.6.5.1834-1837.1986

Published

1986-05-00

Pages

1834-7

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC367714

Subset

Grants

NCI NIH HHS · CA 12421 · United States

External Links

PubMed source DOI: 10.1128/mcb.6.5.1834-1837.1986 PMC Full Text View journal details

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Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.

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