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PMID: 6328284 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.

Molecular and cellular biology ·Vol. 4 ·No. 5 ·1984-05-00 ·Pages 997-1000

Tsichlis PN, Strauss PG, Kozak CA

Abstract

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular sequences which were free of repeated DNA derived from a clone that defines the Mlvi -2 integration domain (lambda Cl228 ) were found to be highly conserved in a variety of vertebrate species that we examined, including mice, hamsters, cats, and humans. In this study, we identified the chromosomal map location of the Mlvi -2 homologous sequences in mice by using hamster-mouse somatic cell hybrids. The results show that Mlvi -2 is present on mouse chromosome 15 but is unrelated to the c-myc and c-sis proto-oncogenes, which map on the same chromosome. Since aberrations on chromosome 15 have been observed reproducibly in mouse thymomas, our data suggest that Mlvi -2 may define a novel sequence involved in the induction or progression of murine thymic lymphomas.

MeSH Terms
Animals Base Sequence Cell Line Chromosome Mapping Clone Cells DNA Restriction Enzymes DNA, Neoplasm/genetics DNA, Viral/genetics Genes, Viral Leukemia, Experimental/microbiology Lymphoma/microbiology Mice Moloney murine leukemia virus/genetics Oncogenes Thymus Neoplasms/microbiology
Chemicals
DNA, Neoplasm DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tsichlis P N
Strauss P G
Kozak C A
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28 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.4.5.997-1000.1984
Published
1984-05-00
Pages
997-1000
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368860
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.4.5.997-1000.1984 PMC Full Text View journal details
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