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PMID: 6326104 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 7 ·1984-04-00 ·Pages 2097-101

Steffen D

Abstract

Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.

MeSH Terms
Animals Base Sequence DNA Restriction Enzymes DNA Transposable Elements DNA, Neoplasm/genetics DNA, Viral/genetics Leukemia Virus, Murine/genetics Leukemia, Experimental/microbiology Lymphoma/genetics,microbiology Mice Mice, Inbred AKR Moloney murine leukemia virus/genetics Nucleic Acid Hybridization Oncogenes Rats
Chemicals
DNA Transposable Elements DNA, Neoplasm DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Steffen D
References (26)
26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.7.2097
Published
1984-04-00
Pages
2097-101
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345444
Subset
IM
Grants
NCI NIH HHS · CA30674 · United States
PHS HHS · P30-12708 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.7.2097 PMC Full Text View journal details
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