Pancreatic glucagon cells contain endorphin-like immunoreactivity.

Histochemistry ·Vol. 59 ·No. 1 ·1978-12-28 ·Pages 75-9

Grube D, Voigt KH, Weber E

Abstract

Semithin and thin serial sections of rat pancreas were investigated by immunocytochemical techniques using antisera against glucagon and endorphin. The immunocytochemical staining methods revealed that in the rat endocrine pancreas endorphin-like immunoreactivity is contained in glucagon (A-) cells. All secretion granules of glucagon cells that could be identified in adjacent thin sections exhibited glucagon as well as endorphin immunoreactivity. Since glucagon cells are devoid of ACTH-like immunoreactivity it is concluded that the biosynthetic pathway of pancreatic endorphin is not the same as in the pituitary.

MeSH Terms

Animals Endorphins/analysis Female Glucagon/analysis Immunoenzyme Techniques Islets of Langerhans/analysis Male Rats

Chemicals

Endorphins Glucagon

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Grube D

Voigt K H

Weber E

References (14)

14 references, click to expand

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Article Info

Journal

Histochemistry

Abbr.

Histochemistry

ISSN

0301-5564

DOI

10.1007/BF00506480

Published

1978-12-28

Pages

75-9

Language

English

Region

Germany

NLM ID

0411300

Subset

External Links

PubMed source DOI: 10.1007/BF00506480

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