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PMID: 355224 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Inducible reactivation and mutagenesis of UV-irradiated bacteriophage P22 in Salmonella typhimurium LT2 containing the plasmid pKM101.

Journal of bacteriology ·Vol. 135 ·No. 2 ·1978-08-00 ·Pages 415-21

Walker GC

Abstract

The inducible (Weigle) reactivation of UV-irradiated bacteriophage P22 has been examined on strains of Salmonella typhimurium with and without the mutagenesis-enhancing plasmid pKM101. A large inducible reactivation was observed in the plasmid-containing strain, but only a small response was observed in the strain lacking the plasmid. An increased frequency of clear-plaque mutants was detected among the survivors. The efficiencies of the plasmid-mediated and cellular repair processes have been determined. The kinetics of induction of the phage reactivation have been investigated. The relationship of the observed results to the inducible reactivation of UV-irradiated lambda in Escherichia coli and to error-prone repair is discussed.

MeSH Terms
Genes, Viral Mutation Plasmids Salmonella Phages/genetics,growth & development,radiation effects Salmonella typhimurium/genetics Ultraviolet Rays Viral Plaque Assay
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Walker G C
References (22)
22 references, click to expand
  1. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.
    Bacteriol Rev. 1976 Dec;40(4):869-907 PMID: 795416
  2. Characterization of an endonuclease associated with the drug resistance plasmid pKM101.
    J Bacteriol. 1977 Aug;131(2):583-8 PMID: 18440
  3. Plasmid modification of radiation and chemical-mutagen sensitivity in Pseudomonas aeruginosa.
    J Gen Microbiol. 1977 Jan;98(1):167-76 PMID: 188973
  4. Isolation and characterization of mutants of the plasmid pKM101 deficient in their ability to enhance mutagenesis and repair.
    J Bacteriol. 1978 Mar;133(3):1203-11 PMID: 346562
  5. Plasmid (pKM101)-mediated enhancement of repair and mutagenesis: dependence on chromosomal genes in Escherichia coli K-12.
    Mol Gen Genet. 1977 Mar 28;152(1):93-103 PMID: 325391
  6. Spontaneous and ultraviolet-induced mutation in Escherichia coli: interaction between plasmid and tif-i mutator effects.
    J Gen Microbiol. 1977 Jul;101(1):163-6 PMID: 330822
  7. Induction of protein X in Escherichia coli.
    Mol Gen Genet. 1977 Feb 15;150(3):237-48 PMID: 321932
  8. Ultraviolet light protection, enhancement of ultraviolet light mutagenesis, and mutator effect of plasmid R46 in Salmonella typhimurium.
    J Bacteriol. 1976 Oct;128(1):271-82 PMID: 789333
  9. Induction kinetics of mutagenic DNA repair activity in E. coli following ultraviolet irradiation.
    Mol Gen Genet. 1976 Oct 18;148(2):125-30 PMID: 790151
  10. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
    Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9 PMID: 1061098
  11. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.
    Proc Natl Acad Sci U S A. 1976 Mar;73(3):950-4 PMID: 768988
  12. An improved bacterial test system for the detection and classification of mutagens and carcinogens.
    Proc Natl Acad Sci U S A. 1973 Mar;70(3):782-6 PMID: 4577135
  13. Effect of rec mutations on the ultraviolet protecting and mutation-enhancing properties of the plasmid R-Utrecht in Salmonella typhimurium.
    Mutat Res. 1973 Sep;19(3):357-9 PMID: 4585477
  14. R-factor-mediated nuclease activity involved in thymineless elimination.
    J Bacteriol. 1974 Jun;118(3):790-5 PMID: 4598004
  15. Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
    Proc Natl Acad Sci U S A. 1975 Mar;72(3):979-83 PMID: 165497
  16. R (transmissible drug-resistance) factors in Salmonella typhimurium: pattern of transduction by phage P22 and ultraviolet-protection effect.
    J Gen Microbiol. 1968 Aug;53(1):109-23 PMID: 4878051
  17. Increase in frequency of ultraviolet-induced mutation brought about by the colicine factor, col-I in Salmonella typhimurium.
    Mutat Res. 1966 Apr;3(2):129-34 PMID: 5333391
  18. Resistance to the bactericidal effect of ultraviolet radiation conferred on Enterobacteria by the colicine factor coli.
    J Gen Microbiol. 1965 Jul;40(1):43-55 PMID: 5323082
  19. Recovery of phage lambda from ultraviolet damage.
    Basic Life Sci. 1975;5A:155-71 PMID: 1103822
  20. R factor-mediated resistance to ultraviolet light in strains of Escherichia coli deficient in known repair functions.
    J Gen Microbiol. 1976 Mar;93(1):103-10 PMID: 772160
  21. Expression of the plasmid pKM101--determined DNA repair system in recA- and lex- strains of Escherichia coli.
    Mol Gen Genet. 1976 Jun 15;145(3):303-6 PMID: 781517
  22. Ultraviolet reactivation and ultraviolet mutagenesis of lambda in different genetic systems.
    Virology. 1971 Feb;43(2):495-503 PMID: 5543835
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.135.2.415-421.1978
Published
1978-08-00
Pages
415-21
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC222398
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.135.2.415-421.1978 PMC Full Text View journal details
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